::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A COMPREHENSIVE STUDY ON ASSOCIATION OF VITAMIN D WITH HDL CHOLESTEROL AND HBA1C IN DIABETIC PATIENTS

AUTHORS:

Dr Muzzamal Hussain, Dr Muhammad Ufeen Akram, Dr Mahmood Ahmad Zahid

ABSTRACT:

Introduction: Vitamin D is a steroid hormone that is initially produced in the skin after exposure to sunlight and is also obtained from dietary sources. Vitamin D deficiency is a common disorder, found in all age groups and in both genders. It is prevalent in various parts of the world including Pakistan. Objectives of the study: The basic aim of the study is to analyze the role of association of Vitamin D with HDL cholesterol and HBA1c in diabetic patients in Pakistan. Methodology of the study: This cross sectional study was conducted in District Headquarters Teaching Hospital, Gujranwala during August 2018 to November 2018 with the permission of ethical committee of hospital. There are 100 diabetic patients from the age range 20 to 60 years were included in this study. After overnight fasting, 10 ml of peripheral blood was withdrawn. Blood samples were centrifuged at 3000 rpm for 10 min and stored at -20°C. Serum levels of 25(OH) D, calcium and fasting serum glucose was measured using Randox kit. Plasma total cholesterol, HDL-C, and triglyceride concentrations were measured in duplicate using enzymatic kits, standardized reagents, and standards. Results: The data was collected from 100 diabetic patients with the mean age range of 57.5 years. 73.4% of the patients were male, 26.6% were female respectively. The mean age of the patients were 57.7±10. The mean HbA1c values of the patients were 9.18±2.52. The mean vitamin D values of the patients were 9.17±3.7. The vitamin D deficiency was in 98.3% of the patients. The collected parameters were compared between good glycemic control patients (HbA1c≤7%) and poor glycemic control patients (HbA1c>7%). Conclusion: It is concluded that HDL correlation was found to be prominent with vitamin D and hence conclusion was validated with respect to HDL. Therefore, the relationship between serum levels of 25(OH) D and lipids may be affected by increased disease duration in these patients. Key words: Diabetes, Diagnostic, Vitamin-D, LDL.