::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

RATE OF OCCURRENCE OF INSULIN RESISTANCE AMONG PATIENTS SUFFERING FROM POLYCYSTIC OVARIAN SYNDROME

AUTHORS:

Dr Ibtisam Ashraf, Dr Amna Zaree, Dr Bilal Arif

ABSTRACT:

Objective: This research work carried out to evaluate the rate of occurrence of IR (Insulin Resistance) in the patients suffering from PCOS (Polycystic Ovarian Syndrome) with the utilization of simple indices of IR and to find out the relationship of PCOS’s clinical manifestations with indices of IR. Methodology: This research work carried out in Shalamar Hospital Lahore during July 2018-july 2019. We included total 100 patients who fulfilled the revised 2003 Rotterdam standard of diagnosis for PCOS. Averages, standard deviations and frequencies were in use for the calculation of the descriptive statistics. The calculation of the IR carried out with the use of level of fasting insulin (> 10.0 IU/ml), fasting insulin: glucose ratio (> 4.50). The calculation of various surrogate marker of insulin resistance as HOMA-IR (> 2.60), QUICK-1 (< 0.3570) & McAuley (< 5.80) carried out. Results: The values for the HOMA-IR, QUICK-1 & McAuley among PCOS patients were 65.0%, 88.0% and 51.20% correspondingly. Patients present with the level of fasting insulin (> 10.0 1U/ml) were 75.320%. Irregularities in menstruation period were the most common presentation followed by infertility, obesity and hirsutism. There was a positive relationship of body mass index (BMI) with different irregularities in menstruation, IR and hyperinsulinemia. Conclusion: There was a significant high frequency of hyperinsulinemia and IR in the patients suffering from PCOS. Most of the clinical manifestation were present to have association with the indices of insulin resistance. Keywords: Presentation, BMI, infertility, insulin, menstruation, PCOS, obesity, frequency, manifestation, fasting, surrogate.