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A RANDOMIZED CONTROL TRIAL TO ASSESS THE COMMON AND PERSISTENT ASSOCIATION OF THYROID IRREGULARITY AMONG HCV PATIENTS

Dr. Fayyaz Hussain Jarwar, Dr. Muhammad Waqar Inaam, Dr. Ahmad Nawaz

Objectives: The objective of the study was to correlate the commonness of thyroid irregularity in persistent hepatitis C patients, managed with pegylated interferon against interferon alpha. Materials & Methods: The design of the study randomized controlled trial carried out at Sir Ganga Ram Hospital, Lahore from July 2016 to September 2017. The number of patients declared with hepatitis C by PSR HCV RNA was three hundred and forty including both males and females. All the enrolled patients for the study was in between twenty-five to sixty years of age. Results: We divide all the patients of our study into two categories. All the patients in category “A” were in between twenty-eight to thirty-three years of age whereas in category “B” the age of patients was in between twenty-seven to forty-four years. Among three hundred and forty patients, the number of male patients was two hundred and one (59.12%) along with one hundred and thirty-nine female patients (40.88%) with a fraction of 2:09:1. The average thyroid energizing hormones range in category “A” was in between was in between (1.19 to 3.43) as well as in category “B” this range was in between (1.48 to 3.44). The number of patients diagnosed with thyroid complication was fifteen (8.82%) in common interferon treatment category along with thirty-one patients (18.24%) in pegylated interferon treatment category (P = 0.011). Conclusion: The researcher declared that all those hepatitis C patients managed with interferon alpha found less commonness of thyroid complication against those who managed with pegylated interferon as well as in both categories’ females were in huge numbers. Keywords: Chronic Hepatitis C (CHC), Pegylated Interferon (peg-IFN), Interferon Alpha (IFN-α) and Thyroid Dysfunction (TD)

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