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IMPLEMENTATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PERIODONTAL DISEASES TREATMENT

V.P. Mudrov, V.N. Nelyubin , I.S. Fomenkov, S.Y. Ivanov

Periodontal diseases, including gingivitis and periodontitis are often associated with progressive loss of periodontal bone and soft tissue. Studies highlight the effectiveness of vascular endothelial growth factor (VEGF) use in periodontitis therapy as it stimulates microvascular perfusion improvement and contributes to connective and bone tissue regeneration. Ten patients at the age 53-79 with diagnosed periodontitis were examined and treated in the department of oral and maxillofacial surgery UKH №4. Besides standard drug therapy, treatment also included VEGF gel which represents a composition of bioresorbable carbohydrates on the basis of carboxymethylcellulose, forming the cellular basis for similar extraclean matrix. Immunohistochemical methods showed a decrease in extracellular secretion of VEGF, as well as the construction of fibers not only from "young" collagen type III, but also collagen type I. Thus, not only stimulation of regeneration was noted, but also a pronounced anti-inflammatory effect of hydrogel with a vascular endothelial growth factor having the potential to stimulate regeneration of periodontal tissues. Key words: periodontal microflora, interferon γ, vascular endothelial growth factor, type I collagen

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