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FREQUENCY OF ACUTE RENAL FAILURE IN PATIENTS OF LIVER CIRRHOSIS ADMITTED IN A TERTIARY CARE HOSPITAL

Muhammad Junaid Aleem, Asma Mahmood

Background: Kidney failure is a common and potentially life-threatening event in patients with cirrhosis, and underlying mechanisms for renal dysfunction are highly variable. Acute kidney failure occurs in approximately 19% of hospitalized patients with cirrhosis. Objective: To find the frequency of acute renal failure in patients of liver cirrhosis Study Design: Descriptive case series Setting: Unit I, Department of Gastroenterology, Lahore general Hospital, Lahore Duration: 6 months: from July 2018 to December 2018 Data Collection Procedure: 175 patients meeting the inclusion criteria were included in the study. Basic demographics like name, age, gender and weight were noted. Blood sample was obtained by using 5 cc BD syringe. Samples were sent to the pathology laboratory of the hospital daily for serial assessment of serum creatinine and GFR during period of admission. Patients were followed for 48 hours, labs were repeated and ARF was labeled, (as per operational definition). All the data was recorded on especially designed proforma (attached). Data was entered and analyzed with IBM-SPSS version 21. Chi-square test was applied with p ≤0.05 taken as significant. Results: The mean age of the study population was 44.29±7.68 years. Majority of the cases were male 137 (78.3%). Child Pugh class when noted, it was found that majority were in child Pugh class B with frequency of 103 (58.9%). There were 119 (68%) with normal weight. Acute renal failure was noted in 37 (21.1%) and 138 (78.9%) were without this condition. Conclusion: Quite a few of cases have the kidney failure in the population presenting with the liver cirrhosis.

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