::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

MORTALITY RISK FACTORS AMONG HOSPITALIZED SMEAR POSITIVE PULMONARY TUBERCULOSIS PATIENTS

AUTHORS:

Dr Samreen Javed, Dr Shabana Shaheen, Dr Manahil Masood

ABSTRACT:

Aim: To assess risk factors that have a significant impact on mortality in patients with positive pulmonary tuberculosis (PTB) test result Methods: A descriptive cross-sectional study was conducted at the Chest Medicine Department of Sir Ganga-ram Hospital Lahore for one-year duration from June 2019 to June 2020. One hundred and seventy (170) Acid Fast Bacilli (AFB) confirmed PTB-positive patients, aged 13 to 80 years, were enrolled in the continuous sampling study, while patients with drug-resistant tuberculosis (TB) and extrapulmonary tuberculosis remained excluded from the study. Selected patients were interviewed to collect demographic and risk factor data using a standardized questionnaire. Results: Out of 170 patients treated with PTB, mortality was found in 23 (13.5%) patients, including 12 (52.2%) men and 11 (47.8%) women. Mortality was significantly related to age (p = 0.003), socioeconomic status (p = 0.019), anemia (p = 0.03), chronic liver disease (CLD) (p = 0.005), diabetes mellitus (DM) (p = 0.001), Human Immunodeficiency Virus (HIV) (p = 0.007), hypertension (HTN) (p = 0.006), recurrent tuberculosis (p = 0.001), and smoking (p = 0.001). Conclusions: Aging, poverty, smoking and the presence of comorbidities such as DM, CLD, HIV, hypertension and anemia are associated with higher mortality in cases of PTB with positive smear results. Keywords: mortality, positive smear, pulmonary tuberculosis, risk factors, coexisting diseases.