::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

COMPARING EFFICACY OF METOCLOPRAMIDE AND DEXAMETHASONE WITH DEXAMETHASONE ALONE IN PREVENTING POSTOPERATIVE VOMITING

AUTHORS:

Dr Ammara Masood, Dr Noor Ul Huda, Dr Muhammad Hashim

ABSTRACT:

Aim: To determine the antiemetic efficacy of the combination of metoclopramide and dexamethasone compared to dexamethasone alone in the prevention of postoperative vomiting in patients undergoing elective abdominal surgery. Study design: Randomized controlled study Place and Duration of Study: In the Department of Anesthesia and Surgical Unit-II of Holy Family Hospital, Rawalpindi for one-year duration from October 2019 to October 2020. Patients and Methods: 120 adult ASA I and II patients undergoing elective surgical procedures were divided into groups A and B, by balloting. Patients were randomized into 2 groups, Group A (n=60) were given Dexamethasone 8mg I/V (2ml), Group B (n=60) were given a combination of metoclopramide 10 mg and dexamethasone 8 mg, 30 – 40 minutes before end of surgery. All patients were observed for 24 hours in the ward for postoperative nausea and vomiting (PONV) postoperatively Results: SPSS-18 was used for data analysis. There were many episodes of vomiting in the ward. Less than two episodes occurred in 74 (61.7%) cases, including 38.3% (23/60) in group A and 85% (51/60) in group B. 2 episodes of vomiting were observed in 31 (25, 8%) and more than 2 episodes of vomiting were reported in 15 (12.5%) cases. Fewer than two episodes of vomiting were significantly high in group B than in group A (85% vs. 38.3%, p = 0.005). Conclusion: A significant reduction in post-operative nausea and vomiting (PONV) was observed during the intraoperative use of dexamethasone and metoclopramide. Key words: metoclopramide, dexamethasone, postoperative nausea and vomiting