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DEMONSTRATE THE DRUG DERIVED FROM OMEGA-3 FATTY ACIDS THERAPEUTIC EFFECT ON PATIENTS WITH OBESITY-ASSOCIATED OSTEOARTHRITIS.

DR. Zainab Isa Ali Abdulla Isa

Objectives: The aim of this study which is published in nature international journal of since on 23.01.2019 11 is to examine the role of macrophages in the progression of obesity-induced osteoarthritis which is mainly progress by synovial inflammation by using clodronate-loaded liposomes (CL) to locally deplete macrophages in the synovial joints. Methodology: An evaluation of Rats where fed with a high-carbohydrate high-fat diet (HCHF) for 16 weeks which already showed: (a) significant increase in body weight 44.39 ± 2.82 g (p < 0.05). (B) Low-density lipoprotein (LDL), and triglyceride were markedly elevated. (C) Osteoarthritis -like changes in articular cartilage. By the D1 (RvD1), which is a unique family of pro-resolving lipid mediator derived from the omega-3 polyunsaturated fatty acid, the study hunt for determine whether RvD1 administration ameliorates obesity-induced osteoarthritis by resolving macrophage-mediated synovitis. Result: shown marked potency in changing the pro-inflammatory behavior of the macrophages in obese mice models. Intra-articular treatment with in the knee joint from mice as follows: (a) decreases macrophages infiltration in synovium, (b) reduces the number of pro-inflammatory macrophages in synovium and (c) improves the severity of synovitis and cartilage degradation. Conclusion: Results provide new evidence for the potential targeting of macrophages in the treatment of obesity-induced osteoarthritis. Key Words: obesity-induced osteoarthritis, omega-3 polyunsaturated fatty acid, synovitis, cartilage degeneration, inflammatory macrophages.

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