ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

HYPOGLYCAEMIA IS ASSOCIATED WITH INCREASED RISK OF FRACTURES IN PATIENTS WITH TYPE2 DIABETES MELLITUS: A COHORT STUDY

, Dr. Muhammad Arslan Mumtaz, Dr. Maryam Zia Bajwa, Dr. Ammad Javaid Chaudhary

This study was conducted to determine that if type 2 diabetes is associated with an increased risk of fracture in patients. This population-based cohort study used data from 2009 to 2017, in which 30,394 participants aged 0–89 years with type 2 diabetes were compared with 303,872 randomly selected age, sex, and practice matched participants without diabetes. Cox regression analysis was used to determine hazard ratios (HRs) for incident fracture in participants with type 2 diabetes. A total of 334,266 participants, median age 34 years, were monitored for 1.9 million person-years. Hazard ratios were lowest in males and females age < 0.001). Secondary analyses or incident hip fractures identified the highest HR of 5.64 (95% CI 3.55–8.97) in men 60–69 years and the highest HR of 5.63 (95% CI 2.25–14.11) in women 30–39 years. Type 2 diabetes was associated with increased risk of incident fracture that began in early age and lasts across the life span. Participants with type 2 diabetes sustained a disproportionately greater number of lower extremity fractures. These findings have important public health implications, given the increasing prevalence of type 2 diabetes and the morbidity and mortality associated with hip fractures. Keywords: Type 2 Diabetes; Increased risk fracture.

FULL TEXT