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ANALYSIS OF INTERFERON AND STAT1 AS THERAPY PREDICTORS IN HEPATITIS INFECTION

Dr Haris Asif, Dr Anum Iftikhar

Abstract: Introduction: Hepatitis is a major public health problem and is endemic throughout the world especially in tropical and developing countries. Objective of the study: The main objective of the study is to analyze the interferon aplha receptors and STAT1 as therapy predictors in hepatitis infection. Methodology of the study: This cross-sectional study was conducted in Baqai Medical College during December 2018 to March 2019. By using non-probability convenience sampling, we enrolled treatment HCV mono-infected and HCV/HBV co-infected patients along with healthy controls. Out of the eligible patients, some were also positive with hepatitis B surface antigen (HbsAg) along with serum HBV-deoxyribonucleic acid (DNA) level. Detailed history was taken from all patients. Results: The data was collected from 100 patients. The demographic values of patient group and control group shows a significant difference. The data suggest clearly that CD4 count decreases in abnormal liver function. There were non-significant relationship present in diseased group treated with different therapies like interferon and glutathione as as p<0.05. The level of micronutrients become decreases in diseased group. Conclusion: It is concluded that hepatitis directly increases the liver enzymes even after receiving medication and other therapies. Expression rate of IFNAR-1 mRNA maybe useful index for predicting long-term efficacy of IFN therapy compared to STAT-1 and IFNAR-2.

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