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CHECK THE ORDER OF PRESCRIPTION OF ANTIHYPERTENSIVE AGENTS AND THEIR ACTION ON BLOOD PRESSURE CONTROL

Dr Farid, Dr. Rafia Arshad, Dr. Fatima Bhatti.

Abstract: Background: Hypertension is included in one of the world most famous disease which is being treated both at monotherapy and common drug level. Objective: The purpose of this study was to check the order of prescription of antihypertensive agents and their action on blood pressure control between hypertensive patients with BMI higher than or lower than 25. Patients and Methods: The sample of this study was manipulated on 150 patients admitted hypertensive patients from 1st April 2017 to 30th June 2018 at Mayo Hospital, Lahore. Only previously known hypertensive patients with or without the complication of hypertension were added in this study, However, newly diagnosed cases or treated as outdoor patients, having white coat hypertension or having indeterminate biography of hypertension were eliminated from the study. A list of question containing biographic details, BP record, associated comorbidities, BMI, the basic biochemical profile including RBS, antihypertensive drug or drugs combination used and any injurious effect was used. By using SPSS, the data was managed. Results: In our study Amlodipine was only calcium channel blocker prescribed, in all cases, it was given to 43 (28.7%), ACEI were prescribed to 45 (30%) of all cases (lisinopril 20%, enalapril 2.6%, ramipril 7.3%). In all cases ARBs were 7 (4.6%) given, 48 (32%) diuretic were given, and 7 (4.6%) beta blockers were given to all patients. 48 (32%) of the patients, the combination was given and as a second-line therapy when one aforementioned drug failed. The target was achieved by 125 patients BP less than 140/90 mmHg by using antihypertensive medication however, target BP was failed to achieve by 33% patients. It was observed that DM of 54% of the subjects was massive and 10% having nephropathy and proteinuria. It was also observed that the history of MI and a history of strokes was 13% and 5% respectively. Conclusion: In this study, it is deduced that tertiary care of Services hospital, use Amlodipine, lisinopril and diuretic as a leading drug. It is also observed that when BMI increases, antihypertensive drugs slowly lose their effectiveness in controlling BP. Key Words: Hypertension, Disease, Monotherapy, Drugs, Prescription, Antihypertensive, Blood Pressure, Agents, BMI and Red Blood Cells.

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