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COMPARATIVE EVALUATION OF SALIVARY ZIN AND COPPER IN ORAL SUB-MUCOUS FIBROSIS PATIENTS AND NORMAL CONTROLS AT ISRA UNIVERSITY, HYDERABAD

Uzma Tariq, Farkhunda Nadeem, Salman Shafique, Summya Qazi

OSMF (Oral submucosal fibrosis),a progressive and irreversible condition results in inability to tolerate spicy food and mouth opening following fibrosis of submucosal tissues .Changes in the oral epithelium precede the submucosal fibrogenesis follows oral epithelial alterations further restricting the tongue movements and making the soft palate fibrosis that may result in Eustachian tube dysfunction as well. It is multifactorial in origin including consuming areca products, red chilies, deficiencies (nutrient and vitamins), altered saliva and genetic factor. Areca is the most common cause of OSMF due to its tannins and arecoline contents with strong fibroblast proliferation potential. This work elaborates and compares the role of changes in the saliva contents of copper and Zinc as a potential cause of OSMF. The male were 44(73.33%) and female 16 (26.67%) with p-value 0.55. Salivary mean copper (Cu) was noted 97.9 ± 17.38 µg/dl in controls group (A) while it was 118.7 ± 7.55 µg/dl in known cases of OSMF (B group) with a significant P-0.000013. Mean Salivary Zn in control group (A) 63.6 ± 17.8 µg/dl while in group B ( Known cases of OSMF) it was 102.5 ± 14.9 µg/dl p-0.00001 (highly significant). Conclusion: There is significant difference between the serum copper and zinc concentration among the normal controls and OSMF patients suggesting their role in the pathogenesis of the disease.

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