- CODEN : IAJPBB
- issn 2349-7750
TITLE:
INSULIN RESISTANCE AS A PREDICTOR OF SENSORY NEUROPATHY IN PREDIABETES
AUTHORS:
Dr.Khursheed Alam, Dr.Talha Bin Liaquat, Dr.Adnan khadim
ABSTRACT:
Aim- The aim of this study is to find the correlation between insulin resistance as a sensory neuropathy predictor in prediabetes. Methodology- In this study level of fast serum insulin was measured and insulin homeostatic assessment model was calculated for all the patients.The study was conducted in Bahawlpur Victoria hospital From January 2018_ January 2019. During the determination of vibration perception threshold VPT by using Biothesiometer, comparison was done of sensory neuropathy in prediabetic patients which those who did have sensory neuropathy. Moreover, between VPT and insulin resistance direct relation was analyzed. Results- For this study total 60 patients were selected having prediabetic cases. The age of selected patients was between 35 to 60 years and the mean age was 48.68 years. In selected subject males were 65% whereas the females were 35%. The minimum level of fasting insulin serum was 3.5 mIU/L whereas the maximum level of fasting serum insulin was 21.8 mIU/L and the mean value was 10.61 ± 4.99 mIU/L. The minimum HOMA-IR was 0.986 and the maximum of it was 6.4 whereas the mean value of it was 2.81 ± 1.37. Using digital Biothrsiometer, according to VPT measured around 43.3% patients had neuropathy. In patients with neuropathy as compared to the patients without neuropathy HOMA-IR (P=0.032) and serum insulin level (P=0.026) was significantly higher. There was significant positive relation found of VPT with HOMA-IR IR (Pearson correlation coefficient = 0.299 [R], 0.281 [L]; P = 0.02 [R], 0.03 [L]) and fasting insulin serum level levels (Pearson correlation coefficient = 0.317 [R], 0.296 [L]; P = 0.013 [R], 0.022 [L]). Conclusion- HOMO-IR, quantified with the help of index and insulin resistance are correlated with the development of sensory neuropathy. Keywords: Prediabetes, Neuropathy, Insulin resistance
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Approved Journal
NLM ID:101711216 [Serial]
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ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
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