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EFFECT OF CPAP AIRWAY REACTIVITY AND AIRWAY INFLAMMATION IN CHILDREN WITH MODERATE-SEVERE ASTHMA

Dr. Uzma Zafar, Dr. Abdullah Hafiz Irshad Ul Haq,Dr. Zahra Mehmood

Background: Asthma indicates airway hyperactivity and airway inflammation. Previously literature has reported that adults with mild well controlled asthma exhibited a marked decrease in airway reactivity (PC20 increased >2-fold) after using nocturnal continuous positive airway pressure (CPAP) for 1 week. If CPAP has positive effect on suppression of airway activity in children who have been suffering from mild-moderate asthma, the chronic use of corticosteroid would decrease. This non-pharmacological therapy would be beneficial in these children. Methods: Children aged 8–17 years with moderate– severe asthma were treated with 4 weeks of nocturnal CPAP (8–10 cm H2O) or sham CPAP ( 8-10 cm h2O). Adherence was monitored with a modem installed in the equipment or by memory cards. Airway reactivity, assessed by methacholine bronchial challenge, was measured prior to and following treatment. Conclusion: Results showed that 4-week treatment with nocturnal CPAP did not produce a twofold suppression of airway reactivity in children with moderate–severe asthma. Keywords: Airway obstruction, mechanical strain, sputum, lung function.

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