Volume : 10, Issue : 02, February – 2023
Title:
07.FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AN ANTI-ANGINAL DRUG
Authors :
Gaddam Mamatha, Zeenath Ruhy
Abstract :
The aim of this work is to prepare fast dissolving tablets of Diltiazem Hydrochloride to improve patient compliance. Tablets containing Diltiazem hydrochloride were formulated using various superdisintegrants like crospovidone (CRP), Croscarmellose sodium(CCS) and sodium starch glycolate(SSG) in concentrations ranging from 2-6%. The tablets were prepared by direct compression method. The flow properties of the granules (F1-F11) were evaluated by determining the Carr’s index, Hausner ratio and angle of repose. Poured density values of different batches were found to range between 0.518 and 0.585gm/ml3, whereas tapped density values were found to vary from 0.641 to 0.668gm/ml3. Carr’s index, Hausner ratio and angle of repose were range between 18.24 to 20.30, 1.22 to 1.25, and 21o40’ to 29o66’ respectively, which indicates that granules prepared exhibit good flow properties. Tablets (F1-F11) were evaluated for tablet properties like thickness, hardness, friability, disintegration time, weight variation, wetting time and drug content uniformity. Disintegration time of formulations (F10 and F11) prepared by sublimation technique was found to be in the range 25.32±0.258 sec to 26.12±0.215 sec. In vitro dissolution study of formulation of F10 (which gave least disintegration time of 25.32±0.258 sec) showed a cumulative release of 78.115 ± 0.162 after 10 min
Keywords: Formulation, Evaluation, Fast Dissolving Tablets, Anti-Anginal Drug
Cite This Article:
Please cite this article in press Gaddam Mamatha et al, Formulation And Evaluation Of Fast Dissolving Tablets Of An Anti-Anginal Drug., Indo Am. J. P. Sci, 2023; 10 (02).
Number of Downloads : 10
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