Volume : 10, Issue : 04, April – 2023
Title:
24.NOVEL POLYMER TECHNOLOGY USED IN PHARMACEUTICAL INDUSTRY
Authors :
Tanushri.p.bawane, dr. Nishan bobade, sampada.u.shelke, vedashri umap, abhishek barathe, varsha rathod
Abstract :
Development of a new drug molecule is costly and requires a long time. Many attempts have been made to improve the safety of the effective level of “old” drugs, utilizing various ways like individualizing drug therapy, curative drug control, and dose titration.
But, recently, important efforts have been made to discover the novel drug releasing systems, which can be supplied to a target system in the human body, while controlling the level and time of delivery. Polymers, whether synthetic or natural, have great importance in pharmaceutical applications, especially in the field of drug delivery. The use of polymers in pharmaceutical applications ranges from their use as binders in tablets to viscosity and flow controlling factors in liquids, and they can be used in suspensions and emulsions; also, insome cases, they can be used as film coatings.
Moreover, they may be used as membranes implanted within the living body. Current work highlights the importance of drug delivery systems and the role of polymers in them.
Cite This Article:
Please cite this article in press Tanushri.p.bawane et al, Novel Polymer Technology Used In Pharmaceutical Industry ., Indo Am. J. P. Sci, 2023; 10 (04).
Number of Downloads : 10
References:
1. Rolando, M.A.; Roque, M. The physical chemistry of materials:energy and environmental applications; CRC. Press, 2016, p. 89.
2. McCrum, N.G.; Buckley, C.P.; Bucknall, C.B. Principles of polymer engineering; Oxford University Press:Oxford, New York, 1997.
3. Painter, P.C.; Coleman, M.M. Fundamentals of polymer science:an introductory text; Technomic Pub.: Lancaster, Pa., 1997.
4. Sowjanya, M.; Debnath, S. Lavanya, P.; Thejovathi, R.; Babu, M.polymers used in the designing of controlled drug delivery system.Res. J. Pharm. and Tech., 2017, 10(3), 903-912. http://dx.doi.org/10.5958/0974-360X.2017.00168.8
5. Mustafa, N.; Mohammed, A.; Omer, A.; Mohamed, E.; Garlnabi,M.; Hamed, A. Reviewing of general polymer types, properties andapplication in medical field. Int. J. Sci. Res. (Ahmedabad), 2016,5(8), 2319-7064.
6. Gandhi, K.J.; Deshmane, S.V.; Biyani, K.R. polymers in pharmaceuticaldrug delivery system: a review. Int.J. Pharm. Sci. Rev.Res., 2012, 14(2), 57-66.
7. Deming, T.J. Polypeptide materials: New synthetic methods andapplications. Adv. Mater., 1997, 9(4), 299- 311.http://dx.doi.org/10.1002/adma.19970090404
8. Siepmann, J.; Faham, A.; Clas, S.D.; Boyd, B.; Jannin, V.;Bernkop-Schnürch, A.; Zhao, H.; Lecommandoux, S.; Evans, J.;Allen, C.; Merkel, O. Costabile, Morgan, R.; Alexander;Ricky, D.Wildman; Roberts, C.; Leroux, J. K. Lipids and Duncan, R.; Ringsdorf, H.; Satchi-Fainaro, R. Polymer therapeutics—polymers as drugs, drug and protein conjugates and gene deliverysystems: Past, present and future opportunities.J. Drug Target.,2006, 14(6), 337-
9. 341.http://dx.doi.org/10.1080/10611860600833856[15] Wen, H.; Jung, H.; Li, X. Drugdelivery approaches in addressingclinical pharmacology-related issues: opportunities and challenges.AAPS J., 2015, 17(6), 1327- 340.http://dx.doi.org/10.1208/s12248-015-9814-9[16] Pillai, O.;
10. Panchagnula, R. Polymers in drug delivery. Curr. Opin.Chem. Biol., 2001, 5, 447- 451.http://dx.doi.org/10.1016/S13675931(00)00227-1[17]
11. Whittlesey, K.J.; Shea, L.Delivery systems for small moleculdrugs, proteins and DNA: the neuroscience/biomaterial interface.Exp. Neurol., 2004, 190, 1-6.http://dx.doi.org/10.1016/j.expneurol.2004.06.020
12. Pang, X.; Du, H.L.; Zhang, H.Q.; Zhai, Y.J.; Zhai, G.X. Polymerdrugconjugates: present state of play and future perspectives. DrugDiscov. Today, 2013, 16, 1316-1322.http://dx.doi.org/10.1016/j.drudis.2013.09.007
13. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumorvascular permeability and the EPR effect in macromolecular therapeutica review. J. Control. Release, 2000, 65, 271284. http://dx.doi.org/10.1016/S0168-3659(99)00248-5
14. Langer, R. New methods of drug delivery. Science, 1990, 249,1527- 1533. http://dx.doi.org/10.1126/science.2218494
15. Freiberg, S.; Zhu, X. Polymer microspheres for controlled drugrelease. Int. J. Pharm., 2004, 282, 1- 18.http://dx.doi.org/10.1016/j.ijpharm.2004.04.013
16. Yang, W.W.; Pierstorff, E. Reservoir-based polymer drug deliverysystems. J. Lab.Autom., 2012, 17(1), 50-58.http://dx.doi.org/10.1177/2211068211428189
17. Stevenson, C.L.; John, T.; Santini, J.; Langer, R. Reservoir-basedrug delivery systemsutilizing micro-technology. Adv. Drug Deliv.Rev., 2012, 64, 1590-1602.http://dx.doi.org/10.1016/j.addr.2012.02.005
18. Blagoeva, R.; Nedev, A. Monolithic controlled delivery systems:Part I. Basiccharacteristics and mechanisms. Bioauto. J., 2006, 480-88.
19. Wise, L.D. Handbook of pharmaceutical controlled release technology;Marcel Dekker,Inc.: New York, Basel, 2000.http://dx.doi.org/10.1201/9781482289985
20. Kydonieus, A. Treatise on controlled drug delivery; Marcel Dekker,Inc.: NewYork, 1992.
21. Chandran, S.; Laila, F.A.; Mantha, N. Design and evaluation of ethyl cellulose based matrix tablets of ibuprofen with pH modulated release kinetics. Indian J. Pharm. Sci., 2008, 5(70), 596-602. http://dx.doi.org/10.4103/0250-474X.45397
22. Gothi, G.D.; Parinh, B.N.; Patel, T.D.; Prajapati, S.T.; Patel, D.M.; Patel, C.N. J. Glob. Pharma Technol., 2010, 2(2), 69-74.
23. Dhikav, V.; Sindhu, S.; Anand, K.S. Newer non-steroidal antiinflammatorydrugs: A review of their therapeutic potential and adversedrug reactions. J. Indian Acad. Clinical Med., 2002, 3, 332338.
24. Nagendrakumar, D.; Keshavshetti, G.G.; Shardor, A.G. An overview:Matrix tablets as sustained release. Recent Res. Sci. Technol.,2013, 5(4), 36-45.
25. Grassi, M. Lapasin, R.; Pricl, S. modeling of drug release from aswellable matrix. Chem. Eng. Commun., 1998, 169, 79-109.http://dx.doi.org/10.1080/00986449808912722
26. Brahmankar, D.M.; Jaiswal, S.B. Biopharmaceutics and Pharmacokinetics,2nd ed;Vallabh Prakashan: Delhi, 2009, pp. 399-401.
27. Manish, J.; Abhay, K. Sustained release matrix type drug deliverysystem: a review.DrugDeliv. Ther., 2012, 2(6), 142-148.
28. Jantzen, G.M.; Robinson, J.R. Sustained and controlled-release drug delivery systems Banker G.S, Rhodes C.T (Eds.) ModernPharmaceutics, Third Edition,Revised and Expanded. Drugs andthe Pharmaceutical Sciences; Marcell Dekker, Inc.New York.,1995, 72, pp. 575-609.
29. Vyas, S.P.; Khar, R.K. Controlled drug delivery: Concepts andadvances.Vallabhprakashan., 2002, pp. 156-189.
30. Zimmer, Ł.; Kasperek, R.; Poleszak, E. Modern polymers in matrixtablets technology.Polim. Med., 2014, 44(3), 189-196.
31. Mesnukul, A.; Yodkhum, K.; Phaechamud, T. Solid dispersionmatrix tablet comprising indomethacin-peg-hpmc fabricated withfusion and mold technique. Indian J. Pharm. Sci.2009, 71(4), 413- 420.http://dx.doi.org/10.4103/0250-474X.57290
32. Venkataraju, M.P.; Gowda, D.V.; Rajesh, K.S.; Shivakumar, H.G.Xanthan and locust bean gum (from ceratoniasiliqua) matrix tablets for oral controlled delivery of metoprolol tartrate. Asian J. Pharm.Sci., 2007, 2(6), 239-248.
33. Vidyadhara, S.; Sasidhar, R.L.C.; Nagaraju, R. Design and developmentof polyethylene oxide based matrix tablets for verapamil hydrochloride. Indian J. Pharm. Sci., 2013, 75(2),185190.
34. Maggi, L.; Segale, L.; Torre, M.L.; Ochoa Machiste, E.; Conte, U.Dissolution behavior of hydrophilic matrix tablets containing twodifferent polyethylene oxides (PEOs) for the controlled release of
35. awater-soluble drug. Dimensionality study. Biomaterials, 2002, 23,1113- 1119.http://dx.doi.org/10.1016/S0142-9612(01)00223-X
36. Bashir, A.; Abbas, S.; Iqbal, Z.; Bahir, S.; Ali, J. Synthesis of crosslinked PVP hydrogelsand its use for the control release of antiasthmaticdrugs. Middle East J. Sci.Res.,2012, 14(2), 273-283.
37. Sreenivasa Rao, B.; Seshasayana, A.; Himasankar, K.; Yalavarthi,P.R.; Kolapalli, R.V. Design and evaluation of ethylene vinyl acetatesintered matrix tablets. Indian J. Pharm. Sci., 2002, 65(5), 496-502.
38. Prakhar, A.; Semimu, L. A. A comprehensive review on sustainedrelease matrix tablets: a promising dosage form. Univers. J. Pharm.Res., 20