Volume : 10, Issue : 07, July – 2023

Title:

09.FORMULATION DEVELOPMENT AND CHARACTERIZATION OF CLOTRIMAZOLE GEL

Authors :

Ketini Bhagya Sree*, Dr T.K.V. Kesav Rao, Mrs. M.Vineela

Abstract :

Objective: Gel is one of the recent technologies in Novel DDS used for dual control release of emulsion and gel for topical use.
Methods: The method used for preparation of micro emulsion w/o was water titration method with Liquid paraffin and propylene glycol as oil phase, Tween 80 and span 80 are used as a surfactant and its concentrations were fixed based on Pseudo ternary phase diagrams. The optimized emulsion formulation was incorporated into the gel matrix that is Carbopol-934, HPMC-5 and HPMC15+ Carbopol-934 by using various concentrations.
Results: The prepared gel were characterized for drug content of gel for physical appearance, drug content, pH, viscosity, spreadability, extrudability and in vitro drug release studies. The optimized formulations showed F9 with 1:3 HPMC15+ Carbopol-934 formulations showed in vitro drug release of 97.82% at the end of 5 h. The optimized formulation showed good drug release within the specified limits.
Conclusion: Clotrimazole was proven to be a suitable candidate for formulating gel for topical delivery to achieve better patient compliance.
Keywords: Clotrimazole, Gel, Topical application, Carbopol-934, HPMC-5, HPMC15+ Carbopol-934, Liquid paraffin, Tween 80, Span 80 and Propylene glycol.

Cite This Article:

Please cite this article in press Ketini Bhagya sree et al, Formulation Development And Characterization Of Clotrimazole Gel., Indo Am. J. P. Sci, 2023; 10 (07).

Number of Downloads : 10

References:

1. Sharma S. et al “Topical Drug Delivery System”available from http://www.pharmainfo.net/ accessed on 12/07/2015.
2. Laithy HM. and El shaboury KMF. The development of Cutina Lipogels and gel microemulsion for topical administration of fluconazole. Ame Pharm Sci. PharmSciTech. 2003; 3:10 25.
3. Kshirsagar N A. Drug Delivery Systems. Ind. J. Pharmacol. 2000; 32:S54- S61.
4. Dadwal Meenakshi, emulgel: a novel approach to topical drug delivery International journal of pharma and bio sciences, 4 (2013), 847-856.
5. Rashmi M. Topical gel: A review august vol. 2008; available from http:// www.pharmainfo.com
6. Sharma S. Topical preparations are used for the localized effects at the site of their application by virtue of drug penetration into the underlying layers of skin or mucous membranes. Pharmaceutical reviews 2008; 6:1.
7. Stanos SP. Topical Agents for the Management of Musculoskeletal Pain .J Pain Symptom Manage March 2007; 33.
8. Jain A, Deveda P, Vyas N, Chauhan J et al. Development Of Antifungal Emulsion Based Gel For Topical Fungal Infection(S). IJPRD 2011; 2(12).
9. Bruton L, Keith P, Blumenthal D, Buxton Z. Goodman & Gillman’s Manual of Pharmacology & Therapeutics. Mc Graw’s Hill. 2008. pp.1086-1094.
10. Cecv G. Preclinical characterisation of NSAIDs in ultradeformable carriers or conventional topical gels. International journal of pharmaceutics; 2008.
11. Bhoyar N, Giri T.K, Tripathi D.K, Alexender .A and Ajazuddin: Recent advances in novel drug delivery system through gels: review, J. Pharm. allied health sci, 2012, 2(2), 21-39.
12. Khullar Rachit,Saini S, Seth N and Rana A C:Emulgels: A surrogate approach for topically used hydrophobic drugs,IJPBS, 2011, 1 (3), 117-128.
13. Prajapati Mehulkumar N, Patel M R, Patel K R & Patel N M:Emulgels: a novel approach to topical drug delivery, IJUPBS, 2013, 2(1), 134- 148
14. Joshi baibhav, Singh Gurpreet, Rana A C, Saini Seema & Singla Vikas: Emulgel: A comprehensive review on recent advancement on topical drug delivery, IRJP, 2011, 2(11), 66-
15. Gaur PK, Mishra S, Purohit S, Dave K. Transdermal Drug Delivery System: A Review. AJPCR 2009; 2: 14-20.
16. Subranayam N, Ghosal SK, Moulik SP. Enhanced In-Vitro Percutaneous Absorption &In-Vivo Anti-Inflammatory Effect of a Selective Cyclooxygenase Inhibitor Using Microemulsion. Drug Dev. & IndustrialPharm., 2005.
17. Pathan, I.B.; Setty, C.M. Chemical penetration enhancers for transdermal drug delivery systems. Trop J Pharm Res. April 2009; 8:173-179.
18. Bonacucina G, Cespi M, Palmieri GF, Characterization & Stability of Emulsion Gels Based on Acrylamide/Sodium Acryloyldimethyl Taurate Copolymer. AAPS PharmSciTech, 10 (2): 34-45, (2009).
19. Curr AEB. Transdermal Drug Delivery: Penetration Enhancement Techniques Heather. Drug Deliv, 5(2):23-33, (2005).
20. Rutrer N, Drug absorption through the skin: a mixed blessing. Arch Dis Child, 62:220- 221, (1987).
21. Zhang XL, Zhao R, Qian W. Preparation of an emulgel for treatment of aphthous ulcer on the basis of carbomers. Chin Pharm J, 30:417-418, (1995).
22. Swarbrick, J. Encyclopedia of pharmaceutical technology, 3rd ed., 1551.
23. WB Saunders Co. Philadelphia, 1970, 55-60.
24. Gupta GD, Gound RS. Release rate of nimesulide from different gellants. Indian J Pharm Sci, 61(1): 229-23, (1999).
25. Chaudhari P, Ajab A, Malpure P, Kolsure P, Sanap D, Development and in-vitro evaluation of thermo reversible nasal gel formulations of Rizatriptan benzoate, Indian J. Pharm. Edu. Res., 2009; 43: 55-62.

</div8