Volume : 10, Issue : 08, August – 2023

Title:

17.A REVIEW ON PHYSICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY SYSTEM
‬

Authors :

Leena Chavan*, Aanchal Mishra, Rushali Sarfare

Abstract :

Novel Drug Delivery System (NDDS) is providing an exceptional improvement in terms of safety, efficacy & quality of conventional drug therapy. Skin is the largest organ present in the body and provides the most convenient route of administration. Transdermal Drug Delivery System (TDDS) is one of the methods introduced under NDDS for providing systemic effect in the body through skin. Although the innovation proves to have maximum patient compliance, it holds limited bioavailability due to the presence of Stratum Corneum, a chief protective skin barrier. A lot of novel advanced transdermal technologies in the form of Penetration Enhancers have been developed to increase bioavailability. This review would discuss the active approaches involved for facilitating drug permeability. It includes renowned methods like Iontophoresis, Sonophoresis, Electroporation, Magnetophoresis, Photomechanical waves, and also other new technologies. This review further highlights certain products under transdermal technologies which are approved and currently in the market. We anticipate that in the future, the limitations of the physical approaches would be overcomed and new advancements along with combination techniques will be in the highlights, resulting in better patient compliance and efficient treatment.
Keywords: drug delivery, novel system, ultrasonic waves, physical transdermal approaches, ultrasound.

Cite This Article:

Please cite this article in press Leena Chavan et al A Review On Physical Penetration Enhancers For Transdermal Drug Delivery System, Indo Am. J. P. Sci, 2023; 10 (08).

Number of Downloads : 10

References:

1. Alkilani AZ, McCrudden MTC, Donnelly RF. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7[4]:438–70.
2. Bala P, Jathar S, Kale S, Pal K. Transdermal Drug Delivery System [TDDS] – A Multifaceted Approach For Drug Delivery. J Pharm Res [Internet]. 2014;8[12]:1805–35.
3. Hafeez A, Singh J, Maurya A, Rana L, Jain U. Recent Advances in Transdermal Drug Delivery System [TDDS]: An Overview. J Sci Innov Res [Internet]. 2013;2[3]:733–44.
4. Prausnitz MR, Langer R. Transdermal Drug Delivery. Nat Biotechnol. 2009;26[11]:1261–8.
5. Nagdev SA, Agrawal O, Usman MRM. Transdermal Drug Delivery System: An Overview. Res J Pharm Technol. 2022;15[3]:1371–7.
6. Riviere JE, Heit MC. Electrically-assisted transdermal drug delivery. Vol. 14, Pharmaceutical Research. 1997. p. 687–97.
7. Yousef H, Alhajj M, Sharma S. Anatomy, Skin [Integument], Epidermis. [Updated 2021 Nov 19]. In: StatPearls [Internet]. Treasure Island [FL]: StatPearls Publishing; 2022 Jan.
8. Jeong WY, Kwon M, Choi HE, Kim KS. Recent advances in transdermal drug delivery systems: a review. Biomater Res. 2021;25[1]:1–15.
9. Rodríguez Cruz, Isabel & Domínguez-Delgado, Clara & Escobar-Chávez, José & López-Cervantes, Miriam & Díaz-Torres, Roberto. Physical penetration enhancers: An overview. Current Technologies to Increase the Transdermal Delivery Of Drugs. 2016;:3–34.
10. Kim JY, Dao H. Physiology, Integument. [Updated 2022 May 8]. In: StatPearls [Internet]. Treasure Island [FL]: StatPearls Publishing; 2022 Jan.
11. Sajid Ali, Maryam Shabbir, Nabeel Shahid. The Structure of Skin and Transdermal Drug Delivery System- A Review. Research J. Pharm. and Tech. 8[2]: Feb. 2015; Page 103-109.
12. Holmgaard R, Nielsen JB. Dermal absorption of pesticides – evaluation of variability and prevention. Danish Environ Prot Agency [Internet]. 2009;[124]:116.
13. Ruela ALM, Perissinato AG, Lino ME de S, Mudrik PS, Pereira GR. Evaluation of skin absorption of drugs from topical and transdermal formulations. Brazilian J Pharm Sci. 2016;52[3]:527–44.
14. Singh I, Morris A. Performance of transdermal therapeutic systems: Effects of biological factors. Int J Pharm Investig. 2011;1[1]:4.
15. Shabbir M, Ali S, Nabeel Shahid M, Rehman K, Amin M, Raza M. Formulation Considerations And Factors Affecting Transdermal Drug Delivery System-A Review. Int J Pharm Integr Life Sci. 2014;2[October 2016]:20–35.
16. Akhtar N, Singh V, Yusuf M, Khan RA. Non-invasive drug delivery technology: Development and current status of transdermal drug delivery devices, techniques and biomedical applications. Biomed Tech. 2020;65[3]:243–72.
17. Kharat, R., & Bathe, R. S. [2016]. A Comprehensive Review on: Transdermal drug delivery systems. International Journal of Biomedical and Advance Research, 7[4], 147.
18. Karande P, Mitragotri S. Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochim Biophys Acta – Biomembr [Internet]. 2009;1788[11]:2362–73.
19. Zorec B, Préat V, Miklavčič D, Pavšelj N. Active enhancement methods for intra- and transdermal drug delivery: A review. Zdr Vestn. 2013;82[5].
20. Bhowmick M, Tamizharasi S, Rathi J, Sonkar S, Shivakumar T. Electrically Assisted Transdermal Therapeutic Devices-An Overview. Res J Pharm Dos Forms Technol. 2010;2[4]:264–9.
21. Dragicevic N, Maibach HI. Percutaneous penetration enhancers physical methods in penetration enhancement. Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. 2017. 1–508 p.
22. Oberli MA, Schoellhammer CM, Langer R, Blankschtein D. Ultrasound-enhanced transdermal delivery: recent advances and future challenges. Ther Deliv. 2014 Jul;5[7]:843-57.
23. Be P, Hart D, Langer R, Blankschtein D, Park D, Ryu H, et al. 19 selected items – PubMed – NCBI Results : 19 Ultrasound -mediated transdermal drug delivery : mechanisms , scope , and emerging trends . experimental study . ultrasound and sodium lauryl sulfate . Perspectives on transdermal ultrasound mediated drug del. 2012;9[4]:8–10.
24. Rawat S, Vengurlekar S, Rakesh B, Jain S, Srikarti G. Transdermal delivery by iontophoresis. Indian J Pharm Sci. 2008;70[1]:5–10.
25. Dhote V, Bhatnagar P, Mishra PK, Mahajan SC, Mishra DK. Iontophoresis: A potential emergence of a transdermal drug delivery system. Sci Pharm. 2012;80[1]:1–28.
26. Ita K. Transdermal iontophoretic drug delivery: Advances and challenges. J Drug Target. 2016;24[5]:386–91.
27. Guy RH, Kalia YN, Delgado-Charro MB, Merino V, López A, Marro D. Iontophoresis: Electrorepulsion and electroosmosis. J Control Release. 2000;64[1–3]:129–32.
28. Meijerink MR, Scheffer HJ, Naranayan G. Irreversible electroporation in clinical practice. Irreversible Electroporation Clin Pract. 2017;[April 2020]:1–285.
29. Weaver JC, Chizmadzhev YA. Theory of electroporation: A review. Bioelectrochemistry Bioenerg. 1996;41[2]:135–60.
30. Ita K. Perspectives on transdermal electroporation. Pharmaceutics. 2016;8[1].
31. A. Charoo N, Rahman Z, A. Repka M, N. Murthy S. Electroporation: An Avenue for Transdermal Drug Delivery. Curr Drug Deliv. 2010;7[2]:125–36.
32. Vaughan TE, Weaver JC. Mechanism of Transdermal Drug Delivery by Electroporation. Electrochemother Electrogenether Transdermal Drug Deliv. 2003;37[4]:187–211.
33. Escobar-Chávez JJ, Bonilla-Martínez D, Villegas-Gonzélez MA, Revilla-Vázquez AL. Electroporation as an efficient physical enhancer for skin drug delivery. J Clin Pharmacol. 2009;49[11]:1262–83
34. Kotnik T, Rems L, Tarek M, Miklavcic D. Membrane Electroporation and Electropermeabilization: Mechanisms and Models. Annu Rev Biophys. 2019;48:63–91.
35. Doukas AG, Kollias N. Transdermal drug delivery with a pressure wave. Adv Drug Deliv Rev. 2004;56[5]:559–79.
36. Lin CH, Aljuffali IA, Fang JY. Correction to: Lasers as an approach for promoting drug delivery via skin. Expert Opin Drug Deliv. 2014;11[12]:1979.
37. Wong TW. Electrical, magnetic, photomechanical and cavitational waves to overcome skin barrier for transdermal drug delivery. J Control Release [Internet]. 2014;193:257–69.
38. Doukas AG, Lee S, Hospital MG. Photomechanical drug delivery. 2000;3916.
39. Donnelly RF, Singh TRR. Novel Delivery Systems for Transdermal and Intradermal Drug Delivery. Novel Delivery Systems for Transdermal and Intradermal Drug Delivery. 2015. 1–268 p.
40. Murthy SN, Sammeta SM, Bowers C. Magnetophoresis for enhancing transdermal drug delivery: Mechanistic studies and patch design. J Control Release [Internet]. 2010;148[2]:197–203.
41. Bala P, Jathar S, Kale S, Pal K. Transdermal Drug Delivery System [TDDS] – A Multifaceted Approach For Drug Delivery. J Pharm Res [Internet]. 2014;8[12]:1805–35.
42. Alkilani AZ, McCrudden MTC, Donnelly RF. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics. 2015;7[4]:438–70.
43. Nagdev SA, Agrawal O, Usman MRM. Transdermal Drug Delivery System: An Overview. Res J Pharm Technol. 2022;15[3]:1371–7.
44. Lokhande R, Gedam B, Shah Y, Tandon M, Bansod PY. Rationale for near total thyroidectomy in patients with nodular goitre. Int J Biomed Adv Res IJBAR Int J Biomed Adv Res J [Internet]. 2015;6[605]:427–30. Available from: www.ssjournals.com
45. Parhi R, Mandru A. Enhancement of skin permeability with thermal ablation techniques: concept to commercial products. Drug Deliv Transl Res. 2021;11[3]:817–41.
46. Jeong WY, Kwon M, Choi HE, Kim KS. Recent advances in transdermal drug delivery systems: a review. Biomater Res. 2021;25[1]:1–15.