Volume : 10, Issue : 09, September – 2023
Title:
12. SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 4-ACETYL MORPHOLINE CHALCONES
Authors :
Gudivada Sridevi*, Mrs. KattepoguNaga Kumari, SK.shakeela Mrs.Chowpati Ramya, Pedamallu Niharika, Mrs. Syed Meraj Sultana, Mrs. Jasmine Shaik
Abstract :
The current study examined that the Chalcones are abundant in edible plants and are considered as the precursors of flavonoids and iso-flavonoids. Claisen–Schmidt condensation is a method used for preparing Chalcones, which is an important class of flavonoids. They have a wide range of biological operations and industrial applications. Due to the excessive importance of β-unsaturated carbonyl moiety and due to a broad range of natural and synthetically designed products, the development of novel synthetic methods remains interested in the research area to synthesize chalcones and their derivatives. According to the results, all the title compounds were purified by recrystallization method using methanol as a solvent. Five compounds were synthesized whose yield generally ranges from 68-95%. So, the 4-dimethyl amino benzaldehyde and salicylaldehyde derivatives were obtained in highest yields, p-hydroxy benzaldehyde, 2-chloro and p- chlorobenzaldehyde derivatives show lowest yield. The chalcone derivatives in the present study were characterized through IR, NMR spectral analysis. Bacillus subtilis was used to screen the compounds for their Anti-bacterial activity using cup-plate method. Compounds-2, 4 and 5 (p-hydroxy benzaldehyde, 2-chloro and p-chlorobenzaldehydes) showed the highest inhibition, while 4-dimethyl amino benzaldehyde showed moderate inhibition and tetracycline was selected as a standard drug.
Keywords: Chalcones derivatives, Claisen–Schmidt condensation technique, Bacillus Subtilis, Tetracycline, Anti-bacterial activity.
Cite This Article:
Please cite this article in press Gudivada Srideviet al,Synthesis And Anti-Microbial Activity Of 4-Acetyl Morpholine Chalcones,Indo Am. J. P. Sci, 2023; 10 (09)..
Number of Downloads : 10
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