Volume : 10, Issue : 09, September – 2023
Title:
26.A REVIEW ON TERATOGENICITY: MECHANISMS OF TERATOGENS AND RISK MANAGEMENT
Authors :
Miss. M Kavya Sree, Mr. V. S. Chandrasekaran*, Dr. M. Kishore Babu
Abstract :
Teratogenicity is recognized as an important part of overall toxicology. The teratogenic risk factors are undetermined for more than 90% of drugs. The common teratogenic mechanism and effects are based on teratogenic compounds and several agents known as physical agents, chemical agents, and biological agents. Millions of different chemicals are exposed by humans and they show negative impacts by penetrating into human tissues, developing fetuses, and the reproductive health of humans. The teratogenic mechanism in pregnancy shows its effects on the developing fetus and sometimes it leads to suppression of fetal growth. It signifies the structural malformations during fetal development. It is a process by which congenital birth defects occur due some biological infections, pharmacological drugs, industrial pollutants, and maternal health problems. Teratology is the science that investigates the congenital malformations and their causes.
Keywords: Teratogenicity, Human tissue, Management teratogens factors
Cite This Article:
Please cite this article in press V. S. Chandrasekaran et al, A Review On Teratogenicity: Mechanisms Of Teratogens And Risk Management, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
References:
1. Duong A, Steinmass c ,Mc-Hale CM, Vaughan CP, Zhang L. Reproductive and developmental toxicity of formaldehyde: a systematic review. Mutat Res 2011; 728: 118-138.
2. Rang HP, Dale MM, Ritter JM, Fowler RJ. Rang and dale’s pharmacology. 6th ed. Edinburgh, UK: Churchill Livingstone; 2007.
3. Gilbert-Bareness E. Teratogenic causes of malformations. Ann Clin Lab Sci 2010; 40: 99-114.
4. Bertollini R, Pagano M, Mastroiacovo P. What is human teratogen: clinical and epidemiological criteria. Ann Ist Super Sanita 1993; 29: 97-104.
5. Briggs GG. Woman’s Health II: drugs in pregnancy. In: Briggs GG, author. Pharmacotherapy self-assessment program 6th edition. 6th ed. Washington, DC: American college of clinical pharmacy publication; 2001.
6. Alwan S, Bleyl SB, Brent RL, Chambers CD, Daston GP, Faustman EM, et al. Teratology primer. 2nd ed. In: Hales B, Scialli A, Tassinari MS. Philadelphia: Thomas Jefferson University; 2010.
7. Meganathan, K. et al. Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells. PLoS One 7, e44228 (2012).
8. West, P. R., Weir, A. M., Smith, A. M., Donley, E. L. R. & Cezar, G. G. Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics. Toxicol. Appl. Pharmacol. 247, 18–27 (2010).
9. Palmer, J. A. et al. Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening. Birth Defects Res. B Dev. Reprod. Toxicol. 98, 343–363 (2013).
10. Amacher, D. E. The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity. Toxicol. Appl. Pharmacol. 245, 134–42 (2010).
11. Hoffmann, D. et al. Performance of novel kidney biomarkers in preclinical toxicity studies. Toxicol. Sci. 116, 8–22 (2010).
12. Farge, E. Mechanotransduction in development. Curr. Top. Dev. Biol. 95, 243–265 (2011).
13. Mammoto, T. & Ingber, D. E. Mechanical control of tissue and organ development. Development 137, 1407–20 (2010).
14. Tam, P. P. L., Loebel, D. A. F. & Tanaka, S. S. Building the mouse gastrula: signals, asymmetry and lineages. Curr. Opin. Genet.Dev. 16, 419–425 (2006).
15. Pouille, P.A., Ahmadi, P., Brunet, A.C. & Farge, E. Mechanical signals trigger myosin II redistribution and mesoderm invagination in Drosophila embryos. Sci. Signal. 2, ra16–ra16 (2009).
16. Desprat, N., Supatto, W., Pouille, P.-A., Beaurepaire, E. & Farge, E. Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos. Dev. Cell 15, 470–477 (2008).