Volume : 10, Issue : 09, September – 2023
Title:
35.FORMULATION AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM CAPTOPRIL AS ANTI- HYPERGLYCEMIC AGENT
Authors :
Bhooma Mounika , Zeenath Ruhy
Abstract :
The present study was aims to formulate and evaluate transdermal drug delivery of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti-hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of Hydro Propyl Methyl Cellulose (HPMC) K15M, Poly Vinyl Pyrrolidone (PVP) K30, ethyl cellulose a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the three polymers by solvent evaporation technique. Dibutyl phthalate and PEG400 were added as plasticizers. Tween-80 and dimethyl sulphoxide (DMSO) were applied as a penetration booster. Several Physicochemical parameters like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness was studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Transdermal patches extended 24-hour drug release was demonstrated in vitro. The formulation F4 performed well in assessment studies, according to the findings of the current experimental inquiry. So, the optimized formulation was the F4 formulation. It was discovered that the penetration of captopril from transdermal formulations follows zero order release and the diffusion mechanism. Therefore, we conclusion that the drug carrier for captopril would be a transdermal delivery method.
Keywords: Captopril, Anti-hypertensive drug, Tween-80, DMSO, Dibutyl phthalate and PEG400
Cite This Article:
Please cite this article in press Bhooma Mounika et al, Formulation And Evaluation Of Transdermal Drug Delivery System Captopril As Anti- Hyperglycemic Agent, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
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