Volume : 10, Issue : 09, September – 2023
Title:
36.PREPARATION AND CHARACTERIZATION OF GLIPIZIDE OSMOTIC TABLETS FOR COLON
Authors :
Sangapaka Bhavani, Zeenath Ruhy
Abstract :
The aim of present study was to prepare and evaluate an osmotic drug delivery system for controlled release of glipizide for treatment of type II noninsulin dependent diabetes mellitus. In order to make bi-layer push-pull osmotic tablets, PEO was used as an expansion agent. Tablets were coated with Opadry CA and mechanically drilled. By changing the percentage of sodium chloride in the push layer, Preparations F10 and F11 were prepared to prevent the drug’s initial delayed release. The drug release was accelerated by increasing the sodium chloride concentration, and the release profile resembled that of the innovator. Preparations F12, F13, and F14 were created by covering them with Opadry CA and achieving weight gains of 8%, 10%, and 12%, respectively, to test the impact of weight growth. When compared to the innovator, preparations F12 and F13 with 8% and 10% of release displayed quick release, while design F14 with 12% of release showed equivalent release. When related to the innovator, the relative release profiles of preparations with 12% and 14% exhibited a like release outline. To obtain the appropriate release profile, a coating of 131% semi-permeable membrane can be advised. However, 12% was decided upon as the optimized mass increase when linked to additional preparations, ultimate F14 as the improved preparation and conducting additional research to scale-up preparations. For three months, stability investigations were carried out at 40 ºC and 75% RH. The optimized preparation F14 was found to be stable and to comply with the Innovator product in terms of appearance, assay, and dissolving profile.
Keywords: Glipizide, Osmotic drug delivery system, Poly ethylene glycol, Opadry CA, Stability.
Cite This Article:
Please cite this article in press Sangapaka Bhavani et al, Preparation And Characterization Of Glipizide Osmotic Tablets For Colon, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
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