Volume : 10, Issue : 09, September – 2023

Title:

37.FORMULATION AND EVALUATION OF RALOXIFENE HYDROCHLORIDE TABLETS TO ENHANCE THE SOLUBILITY

Authors :

Doya Abhilash , Zeenath Ruhy

Abstract :

Poor aqueous solubility and dissolution limit the oral bioavailability of Biopharmaceutics Classification System (BCS) class II drugs. In this study, we aimed to improve the aqueous solubility and oral bioavailability of raloxifene hydrochloride (RLX), a BCS class II drug, using a Solid Dispersions. Solid dispersions were created utilizing the solvent evaporation method at a 1:1 ratio with various carriers, and they demonstrated improved solubility compared to API. Carriers with improved dissolving rates included polyplasdone, polyaxomer, and ß-cyclodextrin. Tablets were prepared by incorporating excipients and evaluated for various pre compression and post compression parameters. Also assay and in-vitro dissolution studies were performed. When the tablets were evaluated, they fell inside the predetermined range. It is determined that inclusion complex (ß-cyclodextrin), hydrophilic polymer (PVA), and surfactant (polaxomer) are used to increase the solubility of raloxifene hydrochloride.
Keywords: Raloxifene Hydrochloride, Cyclodextrin, Polaxomer 407, Poly vinyl pyrrolidone, Solid Dispersions

Cite This Article:

Please cite this article in press Doya Abhilash et al, Formulation And Evaluation Of Raloxifene Hydrochloride Tablets To Enhance The Solubility, Indo Am. J. P. Sci, 2023; 10 (09).

Number of Downloads : 10

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