Volume : 10, Issue : 08, August – 2023
Title:
34.PREPARATION AND CHARACTERISATION OF MICROPARTICULATE DRUG DELIVERY SYSTEM OF DIACEREIN
Authors :
Rangappagari Pravallika , Thadakapally Ramchander
Abstract :
The objective of the present study was to prepare and evaluate the floating microspheres of Diacerein. Diacerein microspheres were prepared by ionotropic gelation method using polymers such as HPMC (K 100 M), Carbopol, Ethyl cellulose and sodium alginate. Totally 12 different formulations of Diacerein were prepared by using the above polymers. The microspheres were characterized for entrapment efficiency, floating property by in vitro wash-off test and in-vitro drug release. Theformulation F9 was selected as an ideal formulation based on the in vitro release profile which shows an extended drug release of 95% upto 12 hours 0.1N HCl buffer. Surface morphology (SEM analysis) and drug-polymerinteraction studies (FT-IR analysis) were performed only for the ideal formulation, F9. The microspheres were discrete, spherical in shape and had ideal surface morphology as confirmed by SEM and FT-IR studies indicated the lack of drug-polymer interactions in the ideal formulation, F9. The in vitro release data of all microsphere formulations were plotted in various kinetic equations to understand the mechanisms and kinetics of drug release. The ideal formulation, F9 followed first order kinetics and value of “n,” is calculated to be 0.7187 indicated that the drug release shows Non-Fickian diffusion.
Keywords: HPMC (K 100 M), Carbopol, Ionotropic gelation method, Diacerein, Sodium Alginate, Ethyl Cellulose
Cite This Article:
Please cite this article in press Rangappagari Pravallika et al, Preparation And Characterisation Of Microparticulate Drug Delivery System Of Diacerein, Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
References:
1. Kumar KR. Floating Microspheres: A Novel Approach in Drug Delivery. J Drug Delivery Res., 2012; 1(4): 1-20.
2. Manivannan R, Baig MA, Purushothaman M, Kumar NS. Formulation and Evaluation of Eletriptan Hydrobromide Microspheres by using Natural Polymers. Int J Pharm Drug Analysis, 2014; 2(3): 347-53.
3. Revathi S, Madhulatha V, Dhanaraju MD. Formulation and Evaluation of Stavudine loaded Sodium Alginate Beads by Ionotropic Gelation Method. Int Res J Pharm, 2014; 5(9): 706-12.
4. Fries A, Anthony RW, Cseko A, Gaither CC, Schulman E .The price and purity of illicit drugs: IDA-P-4332. Institute for Defense Analyses, Virginia, USA, 1981-2007.
5. Kapoor D, Vyas RB, Lad C, Patel M, Sharma S. Formulation and evaluation of stomach specific Floating tablet of anti-ulcer drug. World J Pharm and Pharm Sci., 2014; 3(5): 1534-45.
6. Lachman L, Liberman HA, Kang JL. The theory and practice of industrial pharmacy. 3rd ed. Varghese publication house, 1991; 296-302.
7. Rouge N, Buri P, Doelker E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int J Pharm, 1996; 136: 117-139.
8. Amit Kumar Nayak, Ruma Maji, Biswarup Das. Gastro retentive drug delivery systems: a review, Asian Journal of Pharmaceutical and Clinical Research, 2010; 3(1): 2-10.
9. Manisha P, Ranjava G, Ashok R, Kymonil KM, Subhini SA. Controlled release theophylline loaded buoyant sodium alginate microbeads for prolonged drug delivery to gastric mucosa. J pharm Res., 2010; 3: 758-762.
10. Choi, B. Y., Park, H. J., Hwang, S. J., & Park, J. B. Preparation of alginate beads for floating drug delivery system: effects of CO2 gas-forming agents. International Journal of Pharmaceutics, 2002; 239: 81–91.
11. Ma, N., Xu, L., Wang, Q., Zhang, X., Zhang, W., Li, Y. & Li, S. Development and evaluation of new sustained-release floating microspheres. International Journal of Pharmaceutics, 2008; 358: 82–90.
12. Rohit Shah, Chandrakant Magdum, Shital Kumar Patil, Dhanya Kumar Chougule, Nilofar Naikwade. Validated Spectroscopic Method for Estimation of Aceclofenac from Tablet Formulation. Research J. Pharm. and Tech. 2008; 1(4): 430-432.
13. Balaji M, Abhay A, Gyati S A, Sima S, Ramya M, Omprakash S,Niranjan K. Formulation and Characterization of Polycarbophil Coated Mucoadhesive Microspheres of Repaglinide. J. Pharm. Sci. and Res. 2015; 7(11): 972-977.
14. NM Bhopale, PB Aswar, NB Banarase, SS Khadabadi. Design, Development and In-vitro Evaluation of Sustain Release Rubia cordifolia Matrix Tablet. Research J. Pharm. and Tech. 2008; 1(4): 475-477.
15. Chakraborty Prithviraj, Dey Biplab K., Bahadur Sanjib, Thakkar Suresh, Das Sudip. Design, Development, Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose – Povidone Matrices. Research J. Pharm. and Tech. 2009; 2(1) 168-172
16. VN Deshmukh, JK Jadhav, VJ Masirkar, DM Sakarkar. Formulation, Optimization and Evaluation of Controlled Release Alginate Microspheres Using Synergy Gum Blends. Research J. Pharm. and Tech. 2009; 2 (2): 324-327
17. Nighute AB, Bhise SB. Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres. Research J. Pharm. and Tech. 2009; 2(2): 371-374
18. R Siva Kumar, N Srisutherson, P Kumar Nallasivan, P Arulraj, R Venkatnarayanan. HPTLC Method for the Simultaneous Estimation of Aceclofenac and Diacerein in Tablets Dosage Forms. Research J. Pharm. and Tech. 2010; 3 (3): 825-827.
19. Balaji M, Ramyakrishna N, Hanumanaik M. Formulation Development and Characterization of Enteric Coated Tablets of Lansoprazole. Der Pharmacia Lettre, 2020; 12 (3): 22-38.
20. M. Purushothaman, Sowjanya Battu, K. Jyothshna Devi, C. Madhusudhana Chetty, M. Alagusundaram, K. Mallikarjuna Rao. Formulation and Characterization of Ofloxacin Microspheres Prepared By Ionotropic Gelation Technique. Research J. Pharm. and Tech. 2010; 3 (4): 1265-1269.
21. Balaji M, Ramya KN, Kokkilagadda VK. Preparation and Evaluation of Esomeprazole Enteric Coated Tablets. International Journal of Pharmacy and Pharmaceutical Research. 2020; 18: 16-30.
22. Shah, V. P., Tsong, Y., Sathe, P., & Liu, J.-P. In vitro dissolution profile comparison – Statistics and analysis of the similarity factor, f 2. Pharmaceutical Research, 1998; 15: 889–896
23. Balaji M, Vikas J, Ramya KN, Monika G. Formulation Development and Characterization of controlled release core in cup matrix tablets of venlafaxine HCl. Current Drug Therapy. 2020; 15(5): 503-511.