Volume : 10, Issue : 08, August – 2023
Title:
35.FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF APREPITANT
Authors :
Guje Satish kumar , Thadakapally Ramchander
Abstract :
The present research is directed towards the development of Formulation and evaluation of orodispersible tablets of taste masked Aprepitant to improve the bioavailability of Aprepitant which shows 70%. The Oral Dispersible Tablets (ODTs) of various batches were prepared by using various concentrations of various super disintegrants like sodium starch glycolate, crospovidone and croscarmellose sodium by direct compression method. In the present work nine formulations were prepared using mannitol as diluent, aspartame as sweetener, and talc as glidant. All the prepared ODT formulations were evaluated for physical characteristics, disintegration, In Vitro dissolution and stability study. The hardness of formulations (F1-F9) was in the range of 3.13 – 3.4 Kg/cm2 indicating good mechanical strength and the thickness of formulations were in the range of 5.13 – 5.72 mm. The weight variation and the friability were found within the official limits. The In Vitro dispersion time of all the formulation was done and observed that there is decrease in the In Vitro dispersion time with the increase in the concentration of superdisintegrant. In Vitro dissolution study of all the formulations was carried out for 15 min and according to results formulation F3 was found as the best formulation, which showed 99.5% drug release at the end of 15 min. The selected formulation was subjected for the short-term stability study for 60 days and the hardness, taste, friability, drug content and disintegration were observed and found no significant change in the results.
Keywords: Orodispersible tablets, Aprepitant, Eudragit E100, Mass extrusion method, Superdisintegrant, in-vitro dissolution study.
Cite This Article:
Please cite this article in press Guje Satish kumar et al, Formulation And Evaluation Of Orodispersible Tablets Of Aprepitant, Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
References:
1. Tejvir Kaur, Bhavandeep Gill, Sandeep Kumar, G.D.Gupta; Mouth dissoving tablets: A novel approach to drug delivery; International Journal of Pharmaceutical Research, 2011, vol 3, issue 1, 1-7.
2. Md.Nehal Siddiqui, Garima Garg,Pramod Kumar Sharma; Fast dissolving tablets: Preparation, characterization and evaluation: over view; International Journal of Pharmaceutical Sciences Review and Research, sept-oct 2010, vol 4, issue 2, article 015, 87-96.
3. Jaysukh J Hirani, Dhaval A Rathod, Kantilal R Vadalia; Areview on orally disintegrating tablets; Tropical Journal of Pharmaceutical Research, April 2009, vol 8, issue 2, 161-172.
4. Tablets: Formulation of tablets/Disintegration, www.pharmpedia.com, 2006.
5. Susjit Sahoo, B.Mishra, P.K.Biswal, Omprakash Panda, Santosh Kumar Mahapatra, Goutam Kumar Jana; Fast dissolving tablet: As a potential drug delivery system; Drug Invention Today, 2010, vol 2, issue 2, 130-133.
6. Dali Shukla, Subhashis Chakraborthy, Sanjay Singh, Bramheswar Mishra; Mouth dissolving tablets I- an over view of formulation technology; Scientia Pharmaceutica, 2009, vol 77, 309-326.
7. Sunita Kumari, Sharad Visht, Pramod Kumar Sharma, Rakesh Kumar Yadav; Fast dissolving drug delivery system: review article; Journal of Pharmacy Research 2010, vol 3, issue 6, 1444-1449.
8. Basani Gavaskar, Subash Vijaya Kumar, Guru Sharan, Nagaraju M, Y Madhusudan Rao; Present investigations and future prospects of disintegrating tablets: a review; International Journal of Pharmaceutical Sciences and Research, 2010, vol 1, issue 8, 14-28.
9. M.Swamivelmanickam, R.Manavalan, K.Valliappan; Mouth dissolving tablets: An overview; International Journalof Pharmaceutical Sciences and Research, 2010, vol 1 isuue 12, 43-55.
10. Dali Shukla, Subhashis Chakraborthy, Sanjay Singh, Bramheswar Mishra; Mouth dissolving tablets II- an over view of evaluation techniques; Scientia Pharmaceutica, 2009, vol 77, 327-341.
11. Deabjit Bhowmik, Chiranjib.B, Krishnakanth, Pankaj, RMargret Chandira; An over view on fast dissolving tablets; Journal of Chemical and Pharmaceutical Research, 2009, vol 1, issue 1, 163-177.
12. Tanmoy Ghosh, Amitava Ghosh, Devi Prasad; A review on new generation orodispersible tablets and its future prospective; International Journal of Pharmacy and Pharmaceutical Sciences, 2011, vol 3, issue 1, 1-7.
13. Prashant Khemariya, Kavitha R, Gajbhiye, Vikas Deep Vaidya, Rajesh Singh Jadon, Sachin Mishra, Amit Shukla, Mohit Bhargava, Sanjay K.Singhani, Sanjay Goswami; Preparation and evaluation of mouth dissolving tablets of meloxicam; International Journal of Drug Delivery, 2010, vol 2, 76-80.
14. Metker Vishal, Kumar Anju, Pathak Naveen, Padhee Kumud, Sahoo Sangram; Formulation and evaluation of orodispersible tablets of lornoxicam; International Journal of Drug Development and Research, jan-march 2011, vol 3, issue 1, 281-285.
15. Swathi Daram, Prabhakar Reddy Veerareddy, Raju Jukanti, Suresh Bandari; Formulation and evaluation of ketorolac tromethamine fast dissolving tablets; Scholars Research Library, Der pharmacia letter, 2011, vol 3, issue 2, 97-103.
16. Dr. Srinivasa Rao, Doddayya H, Shrishail S Patil, Vamshidar Reddy.D; Design and evaluation of fast dissolving tablets of taste masked ondansetron hydrochloride; International Journal of Pharma. Research and Development, april 2011, vol 3, issue2, 64-76.
17. Uddav Bagul, Kishore Gujar, Nancy Patel, Sanjeevani Aphale, Shalaka Dhat; Formulation and evaluation of sublimed fast melt tablets of levocetirizine dihydrochloride; International Journal of Pharmaceutical Sciences, 2010, vol 2, 76-80.
18. Basawaraj.S.Patil, N.G.Ragavendra Rao; Formulation and evaluation of fast dissolving tablets of granisetron hydrochloride by vaccum drying technique; Journal of Applied Pharmaceutical Science, 2011, vol 01, issue 04, 83-88.
19. Nagendra Kumar D, Raju S A, Shirsand S B; Formulation design of fast dissolving tablets of fexofenadine hydrochloride by sublimation method; International Journal of Pharma and Bio Sciences, 2010, vol 1, issue 1, 1-7.
20. D.G.Umalkar, B.Stephen Rathinaraj, G.S.Bangale, G.V.Shinde, D.Kumaraswamy, Ch.Rajveer, K S Rajesh; Design and evaluation of mouth dissolving tablets of zopiclone using different superdisintegrants; Journal of Pharmaceutical Sciences and Research, 2010, vol 2, issue 8, 527-533.
21. S Furtado, R Deveswaran, S Bharath, B V Basavaraj, S Abraham, V Madhavan; Development and characterization of orodispersible tablets of famotidine containing a subliming agent; Tropical Journal of Pharmaceutical Research, December 2008, vol 7, issue 4, 1185-1189.
22. Patel Bipin, Dr.J.K.Patel, Rajput Ganesh, Thakor Rashmin; formulation and evaluation of mouth dissolving tablets of cinnarizine; Journal of Pharmacy Research, march 2009, vol 2, issue 3, 510-513.
23. Vijay Tiwari, Dhana jay kinikar, Krishna Pillai, P.D.Gokulan; Preparation and evaluation of fast dissolving tablets of celecoxib; Journal of Current Pharmaceutical Research, 2010, vol 04, 4-11.
24. Ashwini R.Madgulkar, Mangesh R.Bhalekar, Rahul R.Padalkar; Formulation and optimization of novel taste masked mouth dissolving tablets of tramadol having adequate mechanical strength; American Association of Pharmaceutical Scientists PharmSci Tech, june 2009, vol 10, no. 2, 574-581.
25. Sachin B.Mahamuni, Sadhana R.Shahi, Nandakishor V.Shinde, Gaurav R.Agarwal; Formulation and evaluation of fast dissolving tablets of promethazine hcl with masked bitter taste; International Journal of Pharmaceutical Research and Development, sept 2009, vol 7, 1-18.
26. Vineet Bharadwaj, Mayank Bansal, P.K.Sharma; Formulation and evaluation of fast dissolving tablets of amlodipine besylate using different superdisintegrants and camphor as sublimating agent; American-Eurasian Journal of Scientific Research, 2010, vol 5, issue 4, 264-269.
27. Anupama Kalia, Shelly Khurana, Neena Bedi; formulation and evaluation of mouth dissolving tablets of oxcarbazepine; International Journal of Pharmacy and Pharmaceutical Sciences, nov-dec 2009,vol 1, suppl 1, 12-23.