Volume : 10, Issue : 08, August – 2023
Title:
36.FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF PREDNISOLONE
Authors :
Sappidi Supriya, Thadakapally Ramchander
Abstract :
This study’s goal was to develop compression-coated Prednisolone tablets employing pectin, xanthan gum, and HPMC as carriers for an efficient and secure treatment of ulcerative colitis and inflammatory bowel disease. HPMC coated pellets provide more defense against early medicine issue in the upper GI tract than pectin by itself. Tablets were then prepared and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. Based on the amount of medicine released in the colon, crushed covered tablets with a pectin blend were more effective in producing a medicine that targets the colon while releasing the least amount of medication in the other portions of the gastro intestinal tract. The r2 value in the zero order plots is 0.947, while the first order gave 0.909, indicating the link between drug concentration and drug release rate.
Keywords: Prednisolone, Pectin, Xanthan gum, HPMC, invitro release, Kinetics, drug release.
Cite This Article:
Please cite this article in press Sappidi Supriya et al, Formulation And Evaluation Of Colon Targeted Drug Delivery System Of Prednisolone, Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
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