Volume : 10, Issue : 09, September – 2023
Title:
43.PHYTOCHEMICAL ANALYSIS AND ANTI DEPRESSANT ACTIVITY OF MAGNOLIA OFFICINALIS LEAVES EXTRACTS IN EXPERIMENTAL MODELS OF DEPRESSION IN MICE
Authors :
Uppu preethi *, Dr. Sanapala arun kumar
Abstract :
The present study was undertaken to investigate the effects of methanolic extract of Magnolia Officinalis Leaves (family: Magnoliaceae), popularly known as Magnolia Officinalis, on depression using force swim test in rats, potentiation of norepinephrine toxicity in mice and haloperidol induce catalepsy in mice. The extract of Magnolia Officinalis (250 and 500 mg/kg) was administered orally to rats used in FST and 500mg/kg was administered in HIC and same dose administered in NE toxicity in mice. The dose of 250mg/kg and 500mg/kg of extract significantly (p<0.001) reduced the immobility times in rats but dose of 500 mg/kg showed more potent effect than imipramine (30mg/kg). So this dose was used in HIC and NE toxicity in mice. But in NE toxicity model it was observed that MEMO is not good adrenergic component. A significant (P<0.001) reduction in the duration of catalepsy was observed in the MEMO treated group and Fluoxetine group as compared to the haloperidol treated group. In HIC, mice were sacrificed on the seventh day and TBARS, glutathione, nitrite activities were estimated. Monoamine oxidase inhibiting effect and anti-oxidant effect of skullcaps may be contributing favorably to the antidepressant-like activity. Thus, it is concluded that skullcaps extract may possess an antidepressant like effect. Keywords: Magnolia Officinalis, Antidepressant activity, forced swim test.
Cite This Article:
Please cite this article in press Uppu Preethi et al., Phytochemical Analysis And Anti- Depressant Activity Of Magnolia Officinalis Leaves Extracts In Experimental Models Of Depression In Mice, Indo Am. J. P. Sci, 2023; 10 (09).
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