Volume : 10, Issue : 10, October – 2023

Title:

FORMULATION AND IN VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DILTIAZEM HCL

Authors :

Pokury Poorna Chandar Rao*, Mr. Dr. D Venkata Ramana , Mrs. J.Pravalika

Abstract :

The present study involves in the formulation and evaluation of Controlled release tablets of Diltiazem HCl (100mg). The objective of the present study was to formulate Diltiazem hcl Controlled release tablets by Direct compression method by using HPMC K 15M, HPC 2M and HEC 2M. Lactose was used as diluting agent, Magnesium stearate was used as a lubricant and Aerosil was used as a glident. This Controlled release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compressibility index and angle of repose. The formulated tablets were evaluated for physical characteristics of Controlled release tablets such as thickness, hardness, friability, weight variation and drug content. The results of the formulations found to be within the limits specified in official books. The tablets were evaluated for In-vitro drug release studies by using USP type II dissolution test apparatus. The dissolution test was performed in 0.1 N HCL for 2 hr and phosphate buffer pH 6.8 for 12hrs. The in-vitro cumulative drug release profile of all formulations F1-F12 hours showed good drug release. Hence, Formulation F7 was the most promising formulation as it gives satisfactory release (98.29 %) for 12 hours and F7 found to be the best formulation.
Keywords: Diltiazem HCl, HPMC K 15M, HPC 2M and HEC 2M, Controlled release tablets.

Cite This Article:

Please cite this article in press Sirigadha Ramprasad et al, Formulation and in vitro evaluation of controlled release Matrix tablets of diltiazem hcl, Indo Am. J. P. Sci, 2023; 10 (10).

Number of Downloads : 10

References:

1. Sathish Ummadi, B. Shravani, N. G. Raghavendra Rao, M. Srikanth Reddy, B. Sanjeev Nayak.Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences Vol. 3, No. 4 (2013): 258-269.
2. Brahmankar D.M. and Jaiswal S.B. (1995): “Biopharmaceutics and Pharmacokinetics” a Treatise. Vallabh Prakashan, First Edition; 336-337.
3. Lachman Leon, Lieberman Herbert A., Kanig Joseph L. (1996) “The theory and practice of industrial pharmacy” Second edition, Varghese publishing house; Bombay, 171-196.
4. Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics: Pharmacokinetics. 2nd ed. Vallabh Prakashan, Delhi: 2009; 399-401.
5. John C, Morten C, The Science of Dosage Form Design, Aulton: Modified release peroral dosage forms. 2nd ed. Churchill Livingstone. 2002; 290-300.
6. Ali Nokhodchi, Shaista Raja, Pryia Patel, and Kofi Asare-Addo. The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems. Bioimpacts. 2012; 2(4): 175–187.
7. John C, Morten C, The Science of Dosage Form Design, Aulton: Modified release peroral dosage forms. 2nd ed. Churchill Livingstone. 2002; 290-300.
8. Sathish Ummadi, B. Shravani, N. G. Raghavendra Rao, M. Srikanth Reddy, B. Sanjeev Nayak. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences Vol. 3, No. 4 (2013): 258-269.
9. Vyas S,P, Khar RK.Controlled Drug delivery: Concepts and Advances .Concepts and Advances.1st ed.vallabh prakashan,2002,p,156-189.
10. Shargel L,Yu ABC. Modified release drug products. In:Applied Biopharmaceutics and Pharmacokinetics.4th ed.McGraw Hill.1999;169-171.