Volume : 10, Issue : 10, October – 2023

Title:

FORMULATION AND EVALUATION OF ITOPRIDE HYDROCHLORIDE CONTROLLED RELEASE TABLETS

Authors :

Sirigadha Ramprasad *, Mr. Dr.D.Venkata Ramana, Mrs. J.Pravalika

Abstract :

The aim of the present study was to develop controlled release formulation of Itopride hydrochloride to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC K 15M, HEC 2M, HPC 2M were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e., 98.68 % in 12 hours. It contains the HPC 2M polymer. It followed Zero order release kinetics mechanism.
Keywords: Itopride hydrochloride, HPMC K 15M, HEC 2M, HPC 2M and Controlled release tablets.

Cite This Article:

Please cite this article in press Sirigadha Ramprasad et al, Formulation And Evaluation Of Itopride Hydrochloride Controlled Release Tablets, Indo Am. J. P. Sci, 2023; 10 (10).

Number of Downloads : 10

References:

1. Sathish Ummadi, B. Shravani, N. G. Raghavendra Rao, M. Srikanth Reddy, B. Sanjeev Nayak. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences Vol. 3, No. 4 (2013): 258-269.
2. Brahmankar D.M. and Jaiswal S.B. (1995): “Biopharmaceutics and Pharmacokinetics” a Treatise. Vallabh Prakashan, First Edition; 336-337.
3. Lachman Leon, Lieberman Herbert A., Kanig Joseph L. (1996) “The theory and practice of industrial pharmacy” Second edition, Varghese publishing house; Bombay, 171-196.
4. Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics: Pharmacokinetics. 2nd ed. Vallabh Prakashan, Delhi: 2009; 399-401.
5. John C, Morten C, The Science of Dosage Form Design, Aulton: Modified release peroral dosage forms. 2nd ed. Churchill Livingstone. 2002; 290-300.
6. Ali Nokhodchi, Shaista Raja, Pryia Patel, and Kofi Asare-Addo. The Role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems. Bioimpacts. 2012; 2(4): 175–187.
7. John C, Morten C, The Science of Dosage Form Design, Aulton: Modified release peroral dosage forms. 2nd ed. Churchill Livingstone. 2002; 290-300.
8. Sathish Ummadi, B. Shravani, N. G. Raghavendra Rao, M. Srikanth Reddy, B. Sanjeev Nayak. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences Vol. 3, No. 4 (2013): 258-269.
9. Vyas S,P, Khar RK.Controlled Drug delivery: Concepts and Advances .Concepts and Advances.1st ed.vallabh prakashan,2002,p,156-189.
10. Shargel L,Yu ABC. Modified release drug products. In:Applied Biopharmaceutics and Pharmacokinetics.4th ed.McGraw Hill.1999;169-171.