Volume : 10, Issue : 10, October – 2023

Title:

DEVELOPMENT AND EVALUATION OF DOXORUBICIN HYDROCHLORIDE LOADED LIPOSOMES

Authors :

Pankaj, Dr Shabnam Ain* , Dr Babita Kumar, Dr Qurratul Ain

Abstract :

Objective: The objective of this study was to formulate and evaluate liposomes loaded with Doxorubicin.
Methods: Liposomal formulation of Doxorubicin was prepared by “thin lipid film method”. Mixture of phosphotidyl choline (soya lecithin), Doxorubicin and cholesterol of varying weight ratio was used for the preparation of liposomes. All batches were evaluated by drug entrapment and release kinetic studies. Stability study was carried out with F4 batch.
Results: F2 and F4 formulations showed better drug entrapment efficiency compared to the other batches. The drug entrapment efficiency of all batches was found within the range of 51.42 % to 79.0 %. F4 shows highest release of about 79.0% in 4 h. F4 formulation was found to follow significantly zero-order release kinetics. Short term stability study of formulation F4 showed no significant change in release kinetics.
Conclusion: The F4 batches showed promising results compared to other formulations. No changes were founded during the short-term stability study of F4.
Keywords: Liposomes, Doxorubicin, Phosphatidylcholine, Cholesterol, Release kinetics

Cite This Article:

Please cite this article in press Shabnam Ain et al, Development And Evaluation Of Doxorubicin Hydrochloride Loaded Liposomes , Indo Am. J. P. Sci, 2023; 10 (10).

Number of Downloads : 10

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