Volume : 10, Issue : 10, October – 2023
Title:
DESIGN AND EVALUATION OF BILAYER FLOATING TABLETS OF HYDROXY UREA AND RAMOSETRON
Authors :
Narendra Boppana, Priyanka Polavarapu
Abstract :
The purpose of this study to design a bi-layer floating tablets of hydroxy urea (HU) and ramosetron (RS) for delivering multiple pharmaceuticals with atypical release patterns, such as one layer of drug as immediate release (IR) for fast relief and a second layer of drug as sustained release (SR) for long-term effect and reduced dose frequency. The floating layer of HU provides a sustained release by using polymers such as guar gum, carbopal 34 and HPMC K100. The immediate release layer ramosetron developed by using sodium starch glycolate (SSG), crospvidone (CP) as super disintegrants. The tablets are prepared by direct compression method and evaluated for physic chemical parameters such as hardness, thickness, friability, weight variation, in vitro drug release and assay. The optimized formulation (H9) subjected to kinetic release models; the drug release fallows zero order. It can be concluded that the concept of bilayer floating tablets useful for extending the metabolism and improving the bioavailability.
Key words: Bilayer floating tablet, Susatined release, Hydroxy Urea, and Ramosetron
Cite This Article:
Please cite this article in press Narendra Boppana et al, Design And Evaluation Of Bilayer Floating Tablets Of Hydroxy Urea And Ramosetron, Indo Am. J. P. Sci, 2023; 10 (10).
Number of Downloads : 10
References:
1. Gutierrez –Rocca, J. et al, Progresses in gastroretentive drug delivery systems, Drug Dev. Oral., 2003;152-156.
2. Garg, S. et al, Gastroretentive drug delivery systems, Drug Dev. Oral.,2003;160-166.
3. Desai S. A Novel Floating Controlled Release Drug Delivery System Based on a Dried Gel Matrix Network. Jamaica, NY: St John’sUniversity; 1984.
4. Vantrappen GR, Peeters TL, Janssens J. The secretory component of interdigestive migratory motor complexin man. Scand J Gastroenterol. 1979;14:663-667.
5. Wilson CG, Washington N. The stomach: its role in oral drug delivery. In: Rubinstein MH, ed. Physiological Pharmacetical: Biological Barriers to Drug Absorption. Chichester, UK: Ellis Horwood; 1989:47-70.
6. Grubel P. et al, Gastric emptying of non-digestiblesolids in the fasted dog. J. Pharm. Sci. 1987, 76, 117 – 122.
7. Timmermans J, Andre JM. Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: new data for reconsidering the controversy. J Pharm Sci. 1994;83:18-24.
8. Garg S, Sharma S. Gastroretentive drug delivery systems. Business Briefing: Pharmatech 2003 Web Site. 5th edition. May 2003.
9. Bechgaard H, Ladefoged K. Distribution of pellets in gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets. J Pharm Pharmacol. 1978;30:690-692.
10. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release. 2000;63:235-259.
11. Timmermans J, Gansbeke VB, Moes AJ. Assessing by gamma scintigraphy the in vivo buoyancy of dosage forms having known size and floating force profiles as a function of time. Vol I. Proceedings of the 5th International Conference on Pharmacy Technology. Paris, France: APGI; 1989:42-51.
12. Kawashima Y, Niwa T, Takeuchi H, Hino T, Ito Y. Preparation of multiple unit hallow microspheres(microballons) with acrylic resin containing tranilast and their drug release characteristics (invitro) and floating behavior (in-vivo).J.control Release.1991;16:279-290.
13. Rubinstein A, Friend DR. Specific Delivery to the Gastrointestinal Tract. In Polymeric Site Specific Pharmaco Therapy. Domb AJ, Editor. Wiley Chichester.1994; p282-283.
14. Senthilkumar SK, Jaykar B, Kavimani S. Formulation and evaluation of gastroretentive floating drug delivery system of rabeprazole sodium. Int J Biopharm 2011;2(2):57-62.