Volume : 10, Issue : 11, November – 2023

Title:

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF RICINUS COMMUNIS LEAVES GEL FOR HAIR GROWTH ACTIVITY

Authors :

Nilesh Kushwah*, Mr. Manoj Kumar Sahu, Dr. Jitendra Banweer

Abstract :

Hair loss, medically known as alopecia, is a prevalent condition that affects individuals of various ages and genders, causing psychological distress and diminished self-esteem. The search for effective and safe remedies for hair loss has led researchers to explore natural sources, including plant-derived compounds. Ricinus communis, commonly known as the castor oil plant, has been historically used for its medicinal properties, and its leaves are known to contain a diverse range of bioactive compounds.
This abstract presents an overview of the research conducted to investigate the potential of Ricinus communis leaves as a natural remedy for hair loss. The study aimed to explore the phytochemical composition of the leaves, focusing on compounds that could promote hair growth, inhibit hair follicle regression, and provide overall hair health. Extracts from Ricinus communis leaves were obtained using various solvents, and their phytochemical profiles were analyzed using techniques such as gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC).
Furthermore, the research involved in vitro and in vivo experiments to assess the effects of Ricinus communis leaf extracts on hair follicle cells and animal models, respectively. The in vitro experiments included evaluating cell viability, proliferation, and expression of hair growth-related genes upon treatment with different concentrations of leaf extracts. In vivo experiments were conducted on animal models to observe changes in hair regrowth and overall hair health following topical application of formulated leaf extracts.
The findings of the study indicated that Ricinus communis leaf extracts contain a variety of compounds, including fatty acids, flavonoids, and phenolic compounds, which have been reported to possess potential hair growth-promoting properties. The in vitro experiments demonstrated enhanced cell viability, proliferation, and upregulation of key hair growth-related genes, suggesting a positive influence on hair follicle cells. The in vivo experiments revealed promising results, with observed improvements in hair regrowth and follicle health in the animal models treated with the formulated extracts.
In conclusion, the study suggests that Ricinus communis leaves hold promise as a natural source of bioactive compounds that could contribute to the development of hair loss treatments. However, further research is warranted to elucidate the mechanisms of action of specific compounds and to assess the safety and efficacy of formulations for human use. The exploration of plant-derived remedies, such as those derived from Ricinus communis leaves, opens new avenues for the development of innovative and sustainable solutions to address the global challenge of hair loss or alopecia.
Keywords: Ricinus communis leaves, Castor leaves, Hair loss, Alopecia, Natural remedies, Herbal treatments, Traditional medicine, Phytochemicals, Castor oil, Hair growth, Scalp health, Folk remedies, Plant-based therapies, Ricinoleic acid, Essential oils, Topical application, Hair follicles, Herbal extracts, Traditional remedies, Ayurvedic treatments.

Cite This Article:

Please cite this article in press Nilesh Kushwah et al, Phytochemical And Pharmacological Evaluation Of Ricinus Communis Leaves Gel For Hair Growth Activity, Indo Am. J. P. Sci, 2023; 10 (11).

Number of Downloads : 10

References:

1. Somnath D. Bhinge , Mangesh A. Bhutkar , Dheeraj S. Randive , Ganesh H. Wadkar, Sachin S. Todkar , Anil S. Savali , Hariprassanna R. Chittapurkar in Screening of hair growth promoting activity of punica granatum L. ( Pomegranate) leaves extract and it’s potential to exhibit antidandruff and anti-lice effect. Heliyon Journal, Vol. 7, 2021.
2. S. Gejalakshmi, G. Pooja, B. A. Tanisha. Formulation and evaluation of polyherbal hair oil. Drug Invention Today. 13 (1):186-188. 2020.
3. Geeta Parkhe, Deepak Bharti. Phytochemical Investigation and Determination of Total Phenols and Flavonoid Concentration in Leaves Extract of Vitex trifolia Linn. Journal of Drug Delivery & Therapeutics. 9(4-A):705-707. 2019.
4. Dr. Mamta maheshwari, Prabhat Jain, Prachi Sharma, Priyanka Sharma. Antimicrobial activity of hydroalcoholic extract of Juglans regia. Asian Journal of Pharmaceutical Education and Research. 8(3): 1-5. 2019
5. Poonkiat Suchonwanit, Sasima Thammarucha, and Kanchana Leerunyakul, Minoxidil and its use in hair disorders: a review. 2019
6. H. Rambwawasvika, C. T. Parekh, B. Naidoo, and H. Chiririwa, Extraction and characterisation of mucilage from the herb Dicerocaryum senecioides and its use a potential hair permanent, International Journal of Applied Chemistry, vol. 13, pp. 691–705, 2017.
7. Arpana Gaur Mishra, Richa Singh, Neha Patil, Geeta Parkhe. Determination of total phenolic, flavonoid content, antioxidant and antimicrobial activity of gloriosa superb seed extract. Asian Journal of Pharmaceutical Education and Research. 6(2):12-17. 2017.
8. Singh PP, Ambika Chauhan SMS. Activity guided isolation of antioxidants from the leaves of Ricinus communis L. Food Chem . 114(3): 1069-1072. 2019.
9. Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 2016; 79(3): 629 661. 2016.
10. Koparal AT and Bostancıoglu RB. 2016. Promotion of Hair Growth by Traditionally Used Delphinium Staphisagria Seeds through Induction of Angiogenesis. Iranian Journal of Pharmaceutical Research. 15(2): 551- 560. 2016.
11. J. Legrand and R. Villani and E. Roy and K. Khosrotehrani, Journal of Investigative Dermatology, 136(9) 2016.
12. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv; 33(8): 1582-1614. 2015
13. X. Fatima Grace, S. Rahul Raj, S. Shanmughanathan, D. Chamundeeshwari. Preparation and evaluation of polyherbal hair oil. International Journal of Pharmaceutical Chemistry and Analysis. 1(1):1-5. 2014.
14. Kensa V.M., Syhed Yasmi. S, Phytochemical Screening And Antibacterial Activity On Ricinus communis L. Plant Sciences Feed 1 (9): 167-173. 2011.
15. Eudmar Marcolino de Assis Junior, Ismael Malaquias dos Santos Fernandes, Caio Sergio Santos, Luciene Xavier de Mesquita, Rogerio Aparecido Pereira, Patricio Borges Maracaja, Benito Soto-Blanco. Toxicity of castor bean (Ricinus communis) pollen to honeybees Agriculture, Ecosystems and Environment 141: 221–223. 2011.
16. Singh R.K., Gupta M.K., Singh A.K. and Kumar S. Pharmacognostical Investigation Of Ricinus Communis Stem. IJPSR; Vol. 1: Issue 6: 89- 94. 2010.
17. AK Sharma, V Agarwal, R kumar, K Kaushik, P Bhardwaj, H Chaurasia. Development and evaluation of herbal formulation for hair growth. Inter J Curr Trends Sci Tech. 1(3): 147–151. 2010.
18. Lipi Purwal, Surya Prakash B.N Gupta and Milind. S. Pande. Development and Evaluation of Herbal Formulations for Hair Growth. E-Journal of Chemistry. 5(1): 34-38. 2008.
19. DiTomaso JM, and Healy EA. Weeds of California and other western states. UC ANR Publ. 3488. University of California, Division of Agriculture and Natural Resources, Davis, 2007.
20. Kiichiro Yano and Michael Detmar and Lawrence F. Brown and Jack Lawler and Tokichi Miyakawa, Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase, Journal of Investigative Dermatology, 2003, 120, 14-19.
21. Bentley R, Trimen H, Medicinal Plant Vol. 4: 237. 2007.
22. Government of India, Ministry of Health and Family Welfare, Department of Ayush. The Ayurvedic Pharmacopeia of India; Part- І: Vol. ш: 34- 35. 2007.
23. Schreiner M, Schonhof I and Krumbein A. Effect of nitrogen sulfur supply on yield and glucosinolates content of turnip root. Tsingwa Uni Press, 47, 358-359. 2005.
24. Wu L, Woot T, Butrum RR and Chang FH. Part I. Proximate composition mineral and vitamin contents of east Asian foods. In: Food composition table for use in east Asia, 1972.
25. Tamila Heresztyn, Metabolism of volatile phenolic compounds from hydroxycinnamic acids byBrettanomyces yeast in Archives of Microbiology, 1986