Volume : 10, Issue : 12, December – 2023
Title:
TRADITIONAL HERBAL DRUGS USED IN THE TREATMENT OF PEPTIC ULCER
Authors :
Sejal R. Sahu*, Vivek D. Rathod, Dhiraj A. Thaddani , Aniket P. Sawsakade, Dipti Damodar, Pallavi Atalkar
Abstract :
Gastric ulcer is common disorder of digestive system. Current therapeutic regimens largely rely on Western medicine. However, numerous studies have demonstrated that herbal medicines can effectively treat gastric ulcer in humans and various animal models via divergent mechanisms. This review updates the efficacy and safety of herbal medicines in treating gastric ulcer, and the mechanisms of their action in humans and animal models. Studies have demonstrated that the efficacy of herbal medicines is comparable or superior to that of drugs such as omeprazole or cimetidine in humans and animal models, and herbal medicines display fewer adverse effects. The mechanisms by which herbal medicines benefit gastric ulcer include stimulation of mucous cell proliferation, anti-oxidation, and inhibition of gastric acid secretion and H(+)/K(+)-ATPase activity.1Most common sign of peptic ulcer disease (PUD) is a break in the GI tract’s inner lining brought on by either pepsin or gastric acid release. It penetrates the stomach epithelium’s muscularis proporia layer. Usually, it affects the proximal duodenum and stomach.2 Patients with gastric disorders typically experience epigastric discomfort within 15 to 30 minutes after eating, whereas duodenal ulcer patients typically experience pain 2 to 3 hours later.2 Past decade has obviously witnessed a tremendous surge in acceptance and public interest in natural therapies both in developing and developed countries, with these herbal remedies being available not only in drug stores, but now also in food stores and supermarkets. It is estimated that up to four billion people (representing 80% of the world’s population) living in the developing world rely on herbal medicinal products as a primary source of healthcare and traditional medical practice which involves the use of herbs is viewed as an integral part of the culture in those communities. 3
Keywords: Peptic ulcer, H.pylori bacteria, NSAIDs, Traditional herbs, Endoscopy, Gastric cancer.
Cite This Article:
Please cite this article in press Sejal R. Sahu et al, Traditional Herbal Drugs Used In The Treatment Of Peptic Ulcer, Indo Am. J. P. Sci, 2023; 10 (12).
Number of Downloads : 10
References:
1. AUDIBERT, F., JOLIVET, M., CHEDID, L., ARNON, R. & SELA, M. (1982) Successful immunisation with a totally synthetic diphtheria vaccine. Proc. Natn. Acad. Sci. USA. 79, 5042.
2. BEALE, A.J. (1985) Perspective of a traditional manufacturer. In Modern Approaches to The Development of Vaccines (ed. by R. Chanock, R.A. Lerner & F. Brown) Cold Spring Harbor Laboratories, New York, USA. In press.
3. FORMAL, S.B., BARON, L.S., KOPECKO, D.J., WASHINGTON, O., POWELL, C.
& LIFE, C.A. (1981) Construction of a potential bivalent vaccine strain: introduction of shigella sonnei form 1 antigen genes into gal E salmonella typhi Ty2Ia typhoid vaccine strain. Infect. Immun. 34, 746
4. HOISETH, S.K. & STOCKER, B.A.D. (1981) Aromatic dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature, 291, 238. HOWARD, J.G., NICKLIN, S., HALE, C. & LIEW, F.Y.
5. SELA, M. & ARNON, R. (1984) Synthetic antigens and vaccines. Interdisciplinary Sci. Rev. 9, 271.
6. Dannenberg, A. M., Jr (2010). Perspectives on clinical and preclinical testing of new tuberculosis vaccines. Clin Microbiol Rev 23, 781–794
7. Ebensen, T. & Guzma´n, C. A. (2009). Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design. Adv Exp Med Biol 655, 171– 188
8. Ferreira, D. M., Jambo, K. C. & Gordon, S. B. (2011). Experimental human pneumococcal carriage models for vaccine research. Trends Microbiol 19, 464–470.
9. Kaufman, D. R., De Calisto, J., Simmons, N. L., Cruz, A. N., Villablanca, E. J., Mora, J. R. & Barouch, D. H. (2011). Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity. J Immunol 187, 1877–1883.
10. Marzetta, C. A., Lee, S. S., Wrobel, S. J., S
1]Wei-Ping Bi,Hui-Bin Man, and Mao-Qiang Man (2014), Efficacy and safety of herbal medicines in treating gastric ulcer: A review, World Journal of gastroenterology.
2] Talia F. Malik,Karthik Gnanapandithan,Kevin singh,et al(2023),Peptic Ulcer Disease, NIH.
3]Martins Ekor(2014),The growing use of herbal medicines:issues relating to adverse reactions and challenges in monitoring safety ,frontiers in pharmacology.
4]Pandey Mani ,Mehra Neelesh,Kosey Sourabh and Midha Gaurav,et al(2015)Treatment and Replenishment of G.I. Tract with Combined regimen Therapy (CRT) of Allopathic (PPIs)and Ayurvedic (Aloe Vera) Medicine in Peptic Ulcer Disease to Counteract Relapse,Journal of Gastrointestinal And Digestive System.
5]Peter manu(2021), Pharmacological Management of peptic ulcer , NIH.
6] E. Gregory Thompson , & Anne C. Poinier & Adam Husney & Jerome B. Simon, et al (2023).Types of Peptic Ulcer ,HealthLinkBC.
7]Ahmed N. . (2005) 23 years of the discovery of Helicobacter pylori: Is the debate over? Ann Clin Microbiol Antimicrob;4:17
8]Watts G.(2005), Nobel prize is awarded to doctors who discovered H. pylori. BMJ.;331:795
9]Susan chow(2023),Peptic Ulcer History,News medical lifesciences .
10] BS Anand ,Philip O Kartz,et al (2021)Peptic Ulcer Disease Workup,Medscape.
11] Lanza FL, Chan FK,et al(2009) Quigley EM Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. ;104(3):728-738
12] Tang, Jui-Hsiang ; Liu, Nai-Jen ; Cheng, Hao-Tsai ; Lee, Ching-Song ; Chu, Yin-Yi ; Sung, Kai-Feng ; Lin, Cheng-Hui ; Tsou, Yung-Kuan ; Lien, Jau-Min , Cheng, Chi-Liang et al (2009), Endoscopic Diagnosis of Helicobacter pylori Infection by Rapid Urease Test in Bleeding Peptic Ulcers A Prospective Case-Control Study, Journal of Clinical Gastroenterology 43(2):p 133-139.
13] Saurabh Sethi, Daniel Yetman,et al(2023), Can an Endoscopy Diagnose a Stomach Ulcer?, Healthline.
14] Tomica Milosavljevic,Mirjana Kostic-Milosavljevic,Ivan Jovanovic,Miodrag Krstic,et al(2011),Complications of Peptic Ulcer disease,NIH, 29 (5): 491–493.
15] Ertugrul Kayacetin and Serra Kayacetin,et al (2004),Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy,Pubmed central, v.10(12).
16] Soreide K, Thorsen K, Harrison EM, et al.(2015) Perforated peptic ulcer. Lancet. ;386(10000):1288-1298. doi:10.1016/S0140-6736(15)00276-7.
17] Gisbert JP, Legido J, Garcia-Sanz I, Pajares JM,et al, Helicobacter pylori and perforated peptic ulcer prevalence of the infection and role of non-steroidal anti-inflammatory drugs.
18]Andersen IB, Jorgensen T, Bonnevie O, Gronbaek M, Sorensen TI,( 2000) Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: a population-based cohort study. Epidemiology;11:434–439.
19]. Michael J. Proctor, Chris Deans,et al,(2014),Complications of peptic ulcer,ELSEVIR, Volume 32, Issue 11, Pages 599-607.
20] M. Rajeshwari,(2022), ANTI -ULCER ACTIVITY OF MEDICINAL PLANTS-A REVIEW, World Journal of Pharmaceutical Research, Volume 11, Issue 7, 352-364.
21] Hossam S El-Beltagi, Heba I Mohamed, Basma M H Megahed, Mohammed Gamal, Gehan Safwatet al(2018),EVALUATION OF SOME CHEMICAL CONSTITUENTS ,ANTIOXIDANT, ANTIBACTERIAL AND ANTICANCER ACTIVITIES OF BETA VULGARIS L. ROOT ,Fresenius Environment Bulletin,vol-27,pg no.6369-6378.
22]Parle Milind and Gurditta,et al(2011),Basketful benefits of papaya,International Research Journal of Pharmacy,vol-2,6-12.
23] G. Vimala and F. Gricilda Shoba,et al,(2014), A Review on Antiulcer Activity of Few Indian Medicinal Plants, International Journal of Microbiology.
24]M. Indran, A. A. Mahmood, and V. R. Kuppusamy,et al, (2008). “Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats,” West Indian Medical Journal, vol. 57, no. 4, pp. 323–326.
25] A C Ezike,P A AKAH ,C O Okoli,N A Ezeunchenne, S Ezeugwu,et al(2009),Carica papya (Paw-Paw) unripe fruit may be beneficial in ulcer, Med Food,12(6):1268-73.
26] Asmaa Missoum,(2018), An update review on Hibiscus rosa sinensis phytochemistry and medicinal uses, Journal of Ayurvedic and Herbal Medicine,4(3): 135-146.
27]T. Kumari Subitha, M. Ayyanar, M. Udayakumar, and T. Sekar,et al (2011.)“Ethnomedicinal plants used by Kani tribals in Pechiparai forests of Southern Western Ghats, Tamilnadu, India,” International Research Journal Plant Science, vol. 2, no. 12, pp. 349–354.
28]S. Srivastava, J. Jaiswal, H. Gautam, S. Sharma, and C. V. Rao, (2013) “Anti-ulcer activity of methanol extract of Hibiscus rosa sinensis leaves,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, no. 3, pp. 829–830.
29] Thaware Sachin Bhaskarrao , Miss.Khade P, Dr.Hingane L D,et al,(2021) Herbal Potential for Treatment of Peptic Ulcer by Coconut,International Journal of innovative research in technology,vol-8,issue7.
30] Natalia G Vallianou,Penny Gounari,Alexandros Skourtis,John Panagos and Christos Kazazis,et al(2014), Honey and its Anti-Inflammatory, Anti-Bacterial and Anti-Oxidant Properties,Gen Med (Los Angel).
31]Angelica Balingit,Jenna Fletcher,et al(2023),Nine ways to relieve stomach ulcers at home,MedicalNewsToday.
32]Kar, Nihar & Shreechandan, Paikaray & Priyadarshini, Parida & Swain, Sabhya & Sampad,et al (2017). HERBAL DRUGS IN TREATMENT OF PEPTIC ULCER,Journal of bio innovation ,499-508.
33]Taibi Ben Hadda, Naser A.ElSawy,Eslam A.M. Header,Yahia N.Mabkhot and Mohammad S.Mubarak,et al(2014),Effect of garlic and cabbage on healing of gastric ulcer in experimental rats ,medicinal Chemistry Research, pages5110–5119.
34] Prasad, Sahdeo,( 1970).“Turmeric, the Golden Spice.” Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. U.S. National Library of Medicine.
35] Lestari M.L Indrayanto G,et al,(2014), Curcumin, Profiles Drug Subst.Excip .Relat.Methadol. ;39:113-204.
36]Joseph Eichenseher(2018),Peptic Ulcer Disease, science direct.
37]S. Rafatullah,M.Tariq, M.A.Al-Yahya, J.S.Mossa, A.M. Ageel,et al(1990),Evaluation of turmeric(Curcuma longa)for gastric and duodenal antiulcer activity in rats,Journal of Ethnopharmacology,volume 29,Issue1,pg 25-34.
38] Thi Sinh Vo, Tran Thi Bich Chau Vo, Tran Thi Thu Ngoc Vo, and Thi Ngoc Huyen La,et al(2021), Turmeric (Curcuma longa L.): Chemical Components and Their Effective Clinical Applications JOTCSA. 8(3): 883-898.
39]Shamim, Saad Ahmed and Lubna Fatima,et al,(2018) Medicinal properties of Moringa oleifera(Sahajana): A review, The Pharma Innovation.
40] 17. Shamim, Saad Ahmed and Lubna Fatima,et al, (2018), Medicinal properties of Moringa oleifera (Sahajana): A review, The Pharma Innovation.
41] Samir Kumar Sadhu, Emi Okuyama, Haruhiro Fujimoto,Masami Ishibashi, Erdem Yesilada,et al(2006).Prostaglanding inhibitory and antioxidant components of Cistus Laurifolius, a Turkish medicinal plant, Journal of Ethnoppharmacology ,volume108, page no. 371-378.
42] Varsha Sharma, Akshay Katiyar, R.C.Agrawal,et al (2017). Glycyrrhiza glabra: Chemistry and Pharmacological Activity,PubMed Central.
43]SakshiKasat,(2023) Aloe Vera in Different Indian, Languages, India gardening.
44]Amar Surjushe,ReshamVasani, and D G Saple,et al,(2008) ALOE VERA: A SHORT REVIEW, Indian Journal of Dermatology.
45] Yogeshwar Sharma, (2017). Ginger(Zingiber officinale)-an elixir of life a review, The Pharma innovation.
46]Ragvendrahaniadka, Elroy Saldanha,Venkatesh Sunita, PrincyL.Palatty, RajaFayad and Majeshwar ShrinathBaliga,et al(2013) A review of the gastroprotective effects of ginger (ZingiberofficinaleRoscoe), Food and Function.
47]Jun-KyuShin, jae Hyeon Park Kyeong Seok Kim, tong ho Kong HyungSikkim ,et al (2020).Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats, MDPI.
48] Ragvendrahaniadka, Elroy Saldanha, Venkatesh Sunita, PrincyL.Palatty, Raja Fayadand MajeshwarShrinathBaliga,et al,(2013).A review of the gastroprotective effects of ginger (ZingiberofficinaleRoscoe), Food and Function.
49] AwaisAhmed, SalemS.Afghamdi, Kaiser Mahmood And Muhammad Afzal,et al(2015). Fenugreek a multipurpose crop: Potentialities and improvements, Saudi Journal of Biological sciences, page no 301.
50]M. A Kamel, R.Z. Hamza, N.E. Abdel-Hamid,And F.A.Ahmoud,et al(2014)”Antiulcer and gastro protective effects of fenugreek,ginger and peppermint oils in experimentally induced gastric ulcer in rats,”Journal of Chemical and Pharmaceutical research”vol6 no.2Pg no.451-468.
51] Shivangi Goyal, Nidhi Gupta and Sreemoyee, Chatterjee,et al(2022), investigating Therapeutic Potential of Trigonellafoenum-graecum L. as Our Defense Mechanism against several human diseases,NIH.
52] Jacob P.Veenstra and Jeremy J. Johnson,et al,(2019). Oregano(Origanum vulgare) extract for food preservation and improvement in gastrointestinal health,Pubmedcentral.
53] Sepide Miraj, Rafieian-kopaei and Sara kiani,et al,(2016),Melissa officinalsil L:A Review study with an antioxidant prospective, Pubmedcentral.
54] T.Kumar and K.S.Chandrashekar,bauhinia purpurea Linn.et al(2011).A Review of its Ethnobotany Phytochemical Pharmacology Profile.
55] Dr.Bhupendra Vashisht(2013),Disease Ulcers,Aas Ayurveda.
56]Dr. Neelam Sajwan and Dr. Swapnil Singhai et al (2017), EFFECT OF INDIGENOUS SUBSTANCES IN PARINAAM SHOOLA W.S.R. TO DUODENAL ULCER,INTERNATIONAL JOURNAL OF ADVANCED RESEARCH, VOL-5(6),1891.
57]Acharya P.V.Sharma. Dravyaguna Vigyan. Chaukhambha bharti academy: Varanasi, 2013; 2, 254, 761, 149, 195, 616, 114.
58] Malvika Saini and Naresh Kumar et al,(2022), AYURVEDA: A PROMISING HAND FOR CURING DRUG TOXICITY WITH SPECIAL REFERENCE TO PEPTIC ULCERS, World Journal of Pharmaceutical Research, Volume 11, Issue 12, 893-901.
59] Maurya Santosh Kumar, Arka Ghosh, Yadav Amit Kumar, Kumar Dileep, Singh Anil Kumar,ET AL(2014), KAMADUGHA RASA AN EFFECTIVE AYURVEDIC FORMULATION FOR PEPTIC ULCER: A REVIEW,GJRMI,VOL-3,ISSUE 1, 24–32.
60] G. Vimla and F. Gricilda Shobha,et al(2014). A review on Anti ulcer activity of few Indian plants, International Journal of Microbiology.
61] Sistani KarampourN, Arzi A, Rezai A, PashmforooshM, KordiF,et al(2019). Gastroprotective Effect of Zingerone on EthanolInduced Gastric Ulcers in Rats,Europe PMC.
62]Shereen Lehman,(2023). What Drink of food is good for ulcer,Verywell Health.
63]G. Vimla and F. Gricilda Shobha,et al. (2014).”A review on Anti ulcer activity of few Indian medicinal plants”, International Journal of Microbiology.