Volume : 11, Issue : 01, January – 2024

Title:

ORAL WAFERS: A NOVEL APPROACH OF FAST DRUG DELIVERY

Authors :

Sanket D. Badkhal*, Dr. Pankaj M. Pimpalshende, Dr. Satish B. Kosalge

Abstract :

Oral fast disintegrating wafers are a relatively new type of dosage form. They are made thinly with water soluble polymers and quickly dissolve on the tongue or in the buccal cavity. Pharmaceutical technology research has advanced because to wafers’ capacity to transport drugs for systemic action through the oral mucosa without causing hepatic metabolism disturbances. An overview of oral wafers, including their composition, classification, mechanism, formulation, evaluation factors, natural polymers that can be utilized to make wafers, and some previously developed antiemetic medication wafers are provided in this review study.
Keywords: Oral wafer, Fast Dissolving Delivery System, Natural polymers

Cite This Article:

Please cite this article in press Sanket D. Badkhal et al., Oral Wafers: A Novel Approach Of Fast Drug Delivery, Indo Am. J. P. Sci, 2024; 11 (01).

Number of Downloads : 10

References:

1. Patil SB, Daswadkar S. A comprehensive review: natural polymers used for fast dissolving mouth film. International Journal of Pharmaceutical Sciences Review and Research. 2020;65(3):14-21.
2. Hassan Mahboob Muhammad Bilal, RiazTehseen, Jamshaid Muhammad, Bashir Irfan and ZulfiqarSaqiba, Oral Films: A Comprehensive Review, International Current Pharmaceutical Journal, 5(12), 2016, 111-117.
3. Nagar Priyanka, ChauhanIti, YasirMohd, Insights into Polymers: Film Formers in Mouth Dissolving Films, Drug Invention Today, 3(12), 2011, 280-289.
4. Evans RW, Mathew NT. Handbook of Headache. 2nd ed. Lippincott Williams & Wilkins; 2005.
5. Grover VK, Mathew PJ, Hegde H. Efficacy of orally disintegrating ondansetron in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomised, double-blind placebo controlled study. Anaesthesia 2009; 64:595–600.
6. Hanson SM, Singh S, Tabet A, Sastry KJ, Barry M, Wang C. Mucoadhesive wafers composed of binary polymer blends for sublingual delivery and preservation of protein vaccines. Journal of Controlled Release. 2021 Feb 10;330:427-37.
7. Sushmitha S, Priyanka SR, Krishna LM, Murthy MS. Formulation and evaluation of mucoadhesive fast melt-away wafers using selected polymers. Research Journal of Pharmacy and Technology. 2014;7(2):176-80.
8. Chougule K, Dandagi PM, Hulyalkar S. Esomeprazole-Loaded Flash Release Sublingual Wafers: Formulation, Optimization, and Characterization. Journal of Pharmaceutical Innovation. 2023 Sep 2:1-6.
9. Dey P, Ghosh A. Wafers: An innovative advancement of oro- dispersible films. Int. J. App. Pharm. 2016; 8(1):1-7.
10. Masih A, Kumar A, Singh S, Tiwari AK. Fast dissolving tablets: A review. Int. J. Curr. Pharm. Res. 2017; 9(2):8-18.
11. Reddy MR. An introduction to fast dissolving oral thin film drug delivery systems: A review. J. Pharm. Sci& Res. 2020; 12(7):925-40.
12. Joshua JM, Hari R, Jyothish FK, Surendran SA. Fast dissolving oral thin films: An effective dosage form for quick release. Int. J. Pharm. Sci. Rev. Res.2016; 38(1): 282-89.
13. Jurulu NS. Fast dissolving oral films: A review. Int. J. Adv. Pharm. Biol. Chem. 2013; 2(1): 108-12.
14. Karthik DR, Keerthy HS, Yadav RP. A Review on Fast Dissolving Oral Films. Asian J Pharm Res Dev. 2021;9(3): 122-8.
15. Lynthong B, Bhavyashree T, Kamath KK, Shabaraya AR. Oro- dispersible films: AN effective approach for quick dug release. Int. J. Pharm. Rev. Res. 2022; 75(2):180-85.
16. Bhyan B, Jangra S, Kaur M, Singh H. Orally dissolving films innovation formulation and technology. Int J Pharm Sci Rev Res. 2011; 9(2): 50-57.
17. Patil P, Shrivastava SK. Fast Dissolving Oral Films: An Innovative Drug Delivery System. Int. J. Sci. Res. 2014;3(7):2088- 93.
18. Vibhooti P, Preeti K. Wafers technology-a newer approacah to smart drug dilevery system. Indian Journal of Research in Pharmacy and Biotechnology. 2013 May 1;1(3):428.
19. Chopade MS. A Medicated Wafers as a Novel Drug Delivery Carrier: Wafers as a Novel Drug Delivery Carrier. Journal of Drug Delivery and Biotherapeutics. 2023 Nov 9;1(02):16-31.
20. Joshi R, Akram W, Chauhan R, Garud N. Thin Films: A Promising Approach for Drug Delivery System. InDrug Carriers 2022 Mar 27. IntechOpen.
21. Jani R, Patel D. Hot melt extrusion: An industrially feasible approach for casting orodispersible film. asian journal of pharmaceutical sciences. 2015 Jul 1;10(4):292-305.
22. Adel IM, ElMeligy MF, Abdelkhalek AA, Elkasabgy NA. Design and characterization of highly porous curcumin loaded freeze-dried wafers for wound healing. European Journal of Pharmaceutical Sciences. 2021 Sep 1;164:105888.
23. Lade Milind S, PayghanSantosh A, TamboliZaki J, Disouza John I. Polymer based wafer technology: A Review. International Journal of Pharmaceutical & Biological Archives. 2013;4(6):1060-74.
24. Timur SS, Yüksel S, Akca G, Şenel S. Localized drug delivery with mono and bilayeredmucoadhesive films and wafers for oral mucosal infections. International journal of pharmaceutics. 2019 Mar 25;559:102-12.
25. Guo Y, Patanwala HS, Bognet B, Ma AW. Inkjet and inkjet-based 3D printing: connecting fluid properties and printing performance. Rapid Prototyping Journal. 2017 Apr 18;23(3):562-76.
26. Turković E, Vasiljević I, Drašković M, Obradović N, Vasiljević D, Parojčić J. An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. Pharmaceutics. 2021 Mar 30;13(4):468.
27. SumedhaBansal, MayankBansal, GopalGarg, Formulation and Evaluation of Fast Disintegrating Film of An Anti-Hypertensive drug, International Journal of Pharmaceutical, Chemistry and Biological Science, Page no.: 1097-1108.2014
28. Naga SowjanyaJuluru, Fast Dissolving Oral Films: A Review, International Journal of Advances in Pharmacy, Biology and Chemistry, 2013, Page no.: 108-112
29. Ramesh Y, Praveena G, Gobinath M. Medicated Wafers as A Novel Carriers in Drug Delivery System. International Journal of Pharmaceutics and Drug Analysis. 2016 Feb 24:90-7.
30. Boateng J, Burgos-Amador R, Okeke O, Pawar H. Composite alginate and gelatin based bio-polymeric wafers containing silver sulfadiazine for wound healing. International journal of biological macromolecules. 2015 Aug 1;79:63-71.
31. Nagesh G, Santosh J, Audumbar M, Manojkumar P. A review on recent trends in oral drug delivery-lyophilized wafer technology. Int J Res Pharm and Pharm Sci. 2016;1:5-9.
32. Mohammad SZ, Sabry HS, Yousif NZ, Salman ZD. Optimization and evaluation of chlorpheriramine maleate oral strip for paediatric use. Asian J Pharm Clin Res.2018; 11(12):548-54.
33. Costa JS, de Oliveira Cruvinel K, Oliveira-Nascimento L. A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates. Journal of advanced research. 2019 Nov 1;20:33-41.
34. KulkarniVishakha S, Butte Kishor D, RathodSudha S. Natural polymers–A comprehensive review. Int. J. Res. Pharm. Biomed. Sci. 2012 Oct;3(4):1597-613.
35. Alam MT, Parvez N, Sharma PK. FDA-approved natural polymers for fast dissolving tablets. Journal of pharmaceutics. 2014;2014.
36. Jani GK. Gums and mucilages: Versatile excipients for pharmaceutical formulations. Asian J Pharm Sci. 2009; 4(5): 309-32.
37. Shirwaikar A, Prabu SL, Kumar GA. Herbal excipients in novel drug delivery systems. IJPS. 2008; 70: 415-22.
38. Osmałek T, Froelich A, Tasarek S. Application of gellan gum in pharmacy and medicine. International journal of pharmaceutics. 2014 May 15;466(1-2):328-40.
39. Ahuja M, Singh S, Kumar A. Evaluation of carboxymethylgellan gum as a mucoadhesive polymer. International Journal of Biological Macromolecules. 2013 Feb 1;53:114-21.
40. Bangar B, Shinde N, Deshmukh S, Kale B. Natural polymers in drug delivery development. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014;6(1):54-7.
41. Palumbo FS, Federico S, Pitarresi G, Fiorica C, Giammona G. Gellan gum-based delivery systems of therapeutic agents and cells. Carbohydrate polymers. 2020 Feb 1;229:115430.
42. Malabadi RB, Kolkar KP, Chalannavar RK. Natural plant gum exudates and mucilage: pharmaceutical updates. Int J InnovSci Res Rev. 2021;3(10):1897-912.
43. Kulkarni A, Deokule H, Mane M, Ghadge DM, Exploration of Different Polymers for Use in The Formulation of Oral Fast Dissolving Strips, Journal of Current Pharmaceutical Research, 2, 2010, 33-35.
44. Islama S, Mollaa A, Sarkera M, Karima M, Yeum J, Fabrication of Pllulan/Silver Nanoparticle Composite Nanospheres Using Electrospray Technique for Antibacterial Applications, International Journal of Basic & Applied Sciences, IJBAS-IJENS, 11, 2011, 59-69.
45. Singh MC, Pawar SE, Choudhary NH. Preparation and evaluation of powder of unripe fruits of various varieties of musaparadiasiaca L.(Banana and Plantain) as a tablet disintegrant. International Journal of Life Sciences Biotechnology and Pharma Research. 2014 Jul 1;3(3):113.
46. Mengesha Y, Tuha A, Seid Y, Adem AA. Evaluation of Aloe weloensis (Aloeacea) mucilages as a pharmaceutical suspending agent. Advances in pharmacological and pharmaceutical sciences. 2021 May 19;2021:1-6.
47. Setia A, Goyal S, Goyal N. Applications of gum karaya in drug delivery systems: a review on recent research. Der Pharmacia Lettre. 2010;2(5):39-48.
48. Liew K, Younne B, Tan T, Peh KK. Characterization of oral disintegrating film for alzheimer’s disease. AAPS PharmSciTech 2012;13:134-42.
49. Rathborne N, Hadgraft J, Roberts M. Oral thin filmsin orally disintegrating tablet & film technology. Technol Catalysts Int Corporation 2006;4:28-31.
50. Rout SR, Kenguva G, Giri L, Dandela R. Novel salts of the antiemetic drug domperidone: synthesis, characterization and physicochemical property investigation. CrystEngComm. 2023;25(4):513-24.
51. Kelodiya J, Shah SK, Tyagi CK, Budholiya P. Formulation, Development Of Fast Dissolving Sublingual Wafers Of An Antiemetic Drug Using Film Former. Journal of Pharmaceutical Education and Research. 2021;10(4):71-8.
52. Giordani B, Abruzzo A, Prata C, Nicoletta FP, Dalena F, Cerchiara T, Luppi B, Bigucci F. Ondansetronbuccal administration for paediatric use: A comparison between films and wafers. International Journal of Pharmaceutics. 2020 Apr 30;580:119228.
53. Khan WU. Fabrication and evaluation of fast dissolving dosage form of domperidone. Scholar Res Library. 2015;7:136-221.
54. Tambawala TS, Shah PJ, Shah SA. Orally disintegrating tablets of cinnarizine and domperidone: a new arsenal for the management of motion sickness. J Pharm Sci Tech Mgmt. 2015;1:81-97.
55. Ganguly I, Abraham S, Bharath S, Madhavan V. Development of Fast Dissolving Sublingual Wafers of Promethazine Hydrochloride: Development of Fast Dissolving Sublingual Wafers of Promethazine Hydrochloride. Iranian Journal of Pharmaceutical Sciences. 2014;10(1):71-92.
56. Vemula SK, Vangala M. Formulation development and characterization of meclizine hydrochloride sublimated fast dissolving tablets. International scholarly research notices. 2014;2014.