Volume : 11, Issue : 02, February – 2024
Title:
THE RELATIONSHIP BETWEEN CHRONIC KIDNEY DISEASE AND FRAILTY IN GERIATRIC PATIENTS: A SYSTEMATIC REVIEW
Authors :
Mounther Mohammed Alnaim, Maryam Abdullah Almulhim , Sarah Musaed Almulhim,Latifah Abdullatif Aldhaif , Reenad Fahad Almohaish , Ayah Faisal Albash ,Ghezlan Yaqoub Alsabt , Mashael Ahmed Alturki
Abstract :
Objectives: This systematic review synthesizes current evidence on the prevalence of frailty in geriatric patients with chronic kidney disease (CKD), the impact of CKD on frailty development and progression, and the potential mechanisms underlying the relationship between the two conditions. Methods: To discover the pertinent literature, a thorough search was conducted across four main databases: PubMed, MEDLINE, and Embase. Results: We included thirteen studies with a total of 25,191 patients and 11,809 (46.9%) were males. The reported follow-up duration ranged from 3 months to 4 years. The prevalence of frailty among elderly CKD patients ranged from 11.9% to 86% with a total prevalence of 9351 (37.1%). Frailty among elderly CKD patients significantly increased, and higher baseline frailty was linked to higher death. Independent of other confounding factors, these individuals had a significantly higher risk of frailty/pre-frailty when they had increasing age, CKD, MetS, high CKD stage, significant proteinuria, and low serum albumin level, higher concentrations of cystatin C, lower 25OHD, albumin, hemoglobin concentrations, depression, decreased social support, and eGFR. Frailty is linked to increased rates of malnutrition, decreased physical performance, HRQoL, and mental and cognitive problems. Conclusion: Among patients with CKD, frailty is a significant predictor of death, hospitalization, and falls. According to our research, keeping an eye on these patients’ frailty conditions and incorporating that data into a thorough evaluation can help to better direct the therapeutic care of this group. Despite the fact that we discovered a connection between frailty and unfavorable outcomes in CKD, this conclusion should be interpreted cautiously due to the paucity of relevant studies in the literature. Lastly, admitting frailty ought to start conversations with patients about their preferences for future care.
Keywords: Chronic kidney disease; Frailty; Geriatric patients; Comorbidities; Physiological reserve.
Cite This Article:
Please cite this article in press Mounther Mohammed Alnaim et al., The Relationship Between Chronic Kidney Disease And Frailty In Geriatric Patients: A Systematic Review, Indo Am. J. P. Sci, 2024; 11 (02).
Number of Downloads : 10
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