Volume : 11, Issue : 04, April – 2024
Title:
RECENT ADVANCES IN THE PHARMACOLOGICAL DIVERSIFICATION OF FURAN DERIVATIVES
Authors :
Dr.K. Chandrasekhar*, K. Bhavya
Abstract :
Furan is a heterocyclic organic compound consisting of a five-membered aromatic ring with four carbon atoms and one oxygen atom. The class of compounds containing such rings is also referred to as furans. Furan is a colorless, flammable, highly volatile liquid with a boiling point 31.3°C close to room temperature. Furan derivative is an imperative class of heterocyclic compound that has important biological properties. Furan is rapidly and extensively absorbed from the intestine and the lung. It can pass through biological membranes, and enter various organs. Compounds comprising the furan or tetrahydrofuran ring are biologically active and are existent in a number of pharmaceutical products. comprehensive review on Furan and it’s biological activity has unveiled the versatile nature of furan compounds, these molecules exhibit a wide range of biological activities, including anti-malarial, anti-bacterial, anti- cancer, anti-convulsant, anti- oxidant activities. The importance of furan derivatives plays a major role in drug devolpment and therapeutic interventions and it holds premises for the development of novel treatments and medicines, benefitting both scientific advancements and human health.
Cite This Article:
Please cite this article in press K. Bhavya et al., Recent Advances In The Pharmacological Diversification Of Furan Derivatives., Indo Am. J. P. Sci, 2024; 11 (04).
Number of Downloads : 10
References:
1. J. Luo; D. Lu; Y. Peng; Q. Tang, Asian J. Org. Chem., DOI: 10.1002/ajoc.201700340 (2017)
2. F. Chacón-Huet, J. D. Lasso, P. Szavay, J. Covone, P. Forgione, J. Org. Chem., 2021, 86, 515-524.
3. L. Ren, J. Luo, L. Tan, Q. Tang, J. Org. Chem., 2022, 87, 3167-3176.
4. W. Zhao and J. Zhang, Chem. Commun., 46, 4384 (2010).
5. W. Zhao, and J. Zhang, Org. Lett., 13, 688 (2011).
6. L. Zhou, J. Ma, Y. Zhang and J. Wang, Tetrahedron Lett., 52, 5484 (2011)
7. Flynn, B.L.; Gill, G.S.; Grobelny, D.W.; Chaplin, J.H.; Paul, D.; Leske, A.F.; Lavranos, T.C.; Chalmers, 8.D.K.; Charman, S.A.; Kostewicz, E.; et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3- (3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J. Med. Chem. 2011, 54, 6014-6027.
8. Banerjee R, Kumar H, Banerjee M. Medicinal significance of furan derivatives: a review. International Journal of Research in Phytochemistry and Pharmacology. 2015;5(3):48-57.
9. Kalyaev MV, Ryabukhin DS, Borisova MA, et al. Synthesis of 3-Aryl-3-(Furan-2-yl) Propanoic Acid Derivatives, and Study of Their Antimicrobial Activity. Molecules. 2022;27(14):4612.
10. Jagdish K, Gita C, Himanshu G, Mymoona A, Om pT, Malay B. Synthesis and neuropharmacological evaluation of some new isoxazoline derivatives as antidepressant and anti-anxiety agents. African Journal of Pharmacy and Pharmacology. 2013;7(22):1523-30.
11. Gouda MA, Abd El‐Ggani GE, Berghot MA, Khalil AEGM. Synthesis and antioxidant activity of some novel nicotinonitrile derivatives bearing a furan moiety. Journal of Heterocyclic Chemistry. 2019;56(7):2036-45.
12. Kitel R, Byczek-Wyrostek A, Hopko K, Kasprzycka A, Walczak K. Effect of Selected Silyl Groups on the Anticancer Activity of 3,4-Dibromo-5-Hydroxy-Furan-2 (5 H)-One Derivatives. Pharmaceuticals. 2021;14(11):1079.
13. Vera ME, Mariani ML, Aguilera C, Penissi AB. Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5 H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation. International Journal of Molecular Sciences. 2021;22(11):5983.
14. Gündüzalp AB, Parlakgümüş G, Uzun D, et al. Carbonic anhydrase inhibitors: Synthesis, characterization and inhibition activities of furan sulfonylhydrazones against carbonic anhydrase I (hCA I). Journal of Molecular Structure. 2016;1105:332-40.
15. Hosoya T, Aoyama H, Ikemoto T, et al. Dantrolene analogues revisited: General synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle. Bioorganic & medicinal chemistry. 2003;11(5):66