Volume : 11, Issue : 05, May – 2024

Title:

PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF ZIZIPHUS MAURITIANA FOR PEPTIC ULCER

Authors :

Shivam Prajapati, Harshita Jain, Prateek K. Jain, Sunil Kumar Jain, Yashwant Singh Jat, Arpit Shrivastava

This study evaluates the phytochemical and pharmacological properties of the hydroalcoholic extract of Ziziphus mauritiana leaves for its potential anti-ulcerogenic effects. The hydroalcoholic extract exhibited a high yield of 9.2% w/w compared to the petroleum ether extract (1.6% w/w). Phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, saponins, and diterpenes. Quantitative analysis showed the total flavonoid content to be 0.752 mg/100 mg and the total alkaloid content to be 0.347 mg/100 mg of dried extract. In ethanol-induced ulcer models in rats, the hydroalcoholic extract significantly reduced the ulcer index and gastric acidity while increasing gastric pH and reducing pepsin activity. The extract demonstrated dose-dependent anti-ulcerogenic activity, with the 200 mg/kg dose showing the most pronounced effects. These findings suggest that the hydroalcoholic extract of Ziziphus mauritiana possesses significant anti-ulcerogenic properties and may serve as a potential natural therapeutic agent for managing peptic ulcers. Further studies are recommended to explore its mechanisms of action and validate its efficacy and safety in clinical settings.
Key Words: Ziziphus mauritiana, anti-ulcerogenic, hydroalcoholic extract, phytochemical screening, peptic ulcer, ethanol-induced ulcer, gastric acidity, pepsin activity, natural therapeutic agent

Cite This Article:

Please cite this article in press Shivam Prajapati et al., Phytochemical And Pharmacological Evaluation Of Ziziphus Mauritiana For Peptic Ulcere., Indo Am. J. P. Sci, 2024; 11 (05).

Number of Downloads : 10

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