Volume : 11, Issue : 05, May – 2024
Title:
PREPARATION AND EVALUATION OF TRANSDERMAL PATCH CONTAINING DRUG DIACEREIN
Authors :
Srinivas Reddy. Cheedipudi*, Dr.Shaik Harun Rasheed, Sainath Kadam, Rohit Kumar Deo, Sahin Shaikh, Rehola T Yimchunger, Sakshi Baghel
Abstract :
The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polymer matrix.
Matrix type systems were developed in the present study. In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of Diacerein with different concentration of various polymers alone using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. F4formulation has been selected as the best formulation among all the other formulations. The in vitro drug diffusion studies from the formulation were found to be sustained release. All the evaluation parameters obtained from the best formulation were found to be satisfactory. The data obtained from the in vitro release studies were fitted to various kinetic models like zero order, first order, Higuchi model and peppas model. From the kinetic data it was found that drug release follows zero order model release by diffusion technique from the polymer.
Keywords: Transdermal drug delivery, hydrophobic polymers and Diacerein.
Cite This Article:
Please cite this article in press srinivas Reddy. Cheedipudi et al, Preparation And Evaluation Of Transdermal Patch Containing Drug Diacerein.,Indo Am. J. P. Sci, 2024; 11 (5).
Number of Downloads : 10
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