Volume : 11, Issue : 06, June – 2024
Title:
INTEGRATED ANALYSIS OF IMAGING AND SEROLOGICAL MARKERS FOR RISK STRATIFICATION IN ACUTE PULMONARY EMBOLISM
Authors :
Zahra Imran, Shehryar Javed, Aimen Ziafat, Rafey Mehmood Malik, Xi Chang,Mohammad Ali, Mehdi Abbas
Abstract :
Objectives: To explore the association between pulmonary artery obstruction index and serological markers with risk stratification in acute pulmonary embolism(APE).
Methods: The computed tomography pulmonary angiography (CTPA) imaging of patients diagnosed with APE were retrospectively analyzed, and the relevant imaging parameters were measured and calculated. The serological examination results of APE patients were also collected. The relationship of parameters and risk stratification of APE was analyzed by Spearman rank correlation test. The prediction power of parameter with the highest correlation for each risk stratification of APE was tested by the receiver-operating characteristic (ROC) curve.
Results: A total of 62 consecutive patients with APE were categorized into high-risk group (20 cases, 32.26%) and low- and intermediate-risk group (42 cases, 67.74%) according to the guideline. The correlation analysis revealed that Mastora score(r=0.822,p ＜ 0.001) and BNP(r=0.754, p＜0.001) had strong correlation with risk stratification. Between the two groups， Mastora score( area under the curve 0.973，p＜0. 01) and BNP( area under the curve 0. 914，
p＜0. 01) had the strongest prediction power for the high-risk group, respectively.
Conclusions: Mastora score and BNP are associated with risk stratification in patients with acute pulmonary embolism.
Key Words: Acute pulmonary embolism, Computed tomography pulmonary angiography, Mastora score, BNP
Cite This Article:
Please cite this article in press Zahra Imran et al., Integrated Analysis Of Imaging And Serological Markers For Risk Stratification In Acute Pulmonary Embolism., Indo Am. J. P. Sci, 2024; 11 (06).
Number of Downloads : 10
References:
[1] Law Y, Chan YC, Cheng SWK. Epidemiological updates of venous thromboembolism in a Chinese population. Asian J Surg. 2018 Mar;41(2):176-182.
[2] Torbricki A ， Perrier A ， Konstantinides S ， et al. Guidelines on the diagnosis and management of acute pulmonary embolism : the task force for the European Society of cardiology( ESC) . Eur Heart J, 2008，29: 2276-2315.
[3] Righini M, Robert-Ebadi H, Le Gal G. Diagnosis of acute pulmonary embolism. J Thromb Haemost. 2017 Jul;15(7):1251-1261.
[4] Ruggiero A, Screaton NJ. Imaging of acute and chronic thromboembolic disease: state of the art[J]. Clin Radiol. 2017 May;72(5):375-388.
[5] Ruiz Y, Caballero P, Caniego JL, et al. Prospective comparison of helical CT with angiography in pulmonary embolism: global and selective vascular territory analysis. Interobserver agreement[J]. Eur Radiol,2003,13(4):823-829.
[6] Mastora I, Remy-Jardin M, Masson P et al. Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data. Eur Radiol 2003;13(1):29–35.
[7] Qanadli SD, El Hajjam M, Vieillard-Baron Aet al. New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. AJR Am J Roentgenol 2001; 176(6):1415–1420.
[8] YU Jing, GUO Xuejun. CT Obstruction Index to Quantify Arterial Obstruction in Pulmonary Embolism. Chin J Respir Crit Care Med,2010, 401-403.
[9] Gutte H, Mortensen J, Jensen CV, von der Recke P, Petersen CL, Kristoffersen US, Kjaer A. ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism. Clin Physiol Funct Imaging. 2010 Nov;30(6):466-72.
[10] Stavros K，Adam T，Giancarlo A，et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the task force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology ( ESC) . Eur Heart J, 2014, Aug; 29
[11] YIN Chunlin，WEI Jiaping，HAO Hengjian，XIA Jinggang，FAN Zhenxing，XU Ji，XU Dong. Non-specific clinical features and analysis of the cause of misdiagnosis of acute pulmonary embolism. Journal of Cardiovascular ＆ Pulmonary Diseases, 2012, 31: 591-595.
[12] Becattini C, Agnelli G, Lankeit M, et al. Acute pulmonary embolism: Mortality prediction by the 2014 European Society of Cardiology risk stratification model. Eur Respir J, 2016, 48(3):ERJ-00024-2016.
[13] Zagorski J，Sanapareddy N，Gellar MA，et al. Transcriptional profile of right ventricular tissue during acute pulmonary embolism in rats. Physiol Genomics，2008，34: 101-111.
[14] Sanchez O，Planquette B，Meyer G. Update on acute pulmonary embolism. Eur espir Rev, 2009, 18: 137-147.
[15] Ghaye B，Ghuysen A，Willems V，et al，Severe pulmonary embolism: pulmonary artery clot load scores and cardiovascular parameters as predictors of mortality. Radiology，2006， 239: 884-891.
[16] Zhao DJ，Ma DQ，He W，et al. Cardiovascular parameters to assess the severity of acute pulmonary embolism with computed tomography. Acta Radiol，2010，51: 413-419.
[17] Chaosuwannakit N，Makarawate P. Prognostic value of right ventricular dysfunction and pulmonary obstruction index by computed tomographic pulmonary angiography in patients with acute pulmonary embolism. J Med Assoc Thai，2012，95: 1457-1465.
[18] Irmak I, Sertçelik Ü, Öncel A, Er B, İnam G, Durhan G, Demir A, Çöplü L. Correlation of thrombosed vessel location and clot burden score with severity of disease and risk stratification in patients with acute pulmonary embolism. Anatol J Cardiol. 2020 Oct;24(4):247-2