Volume : 11, Issue : 06, June – 2024
Title:
FORMULATION AND EVALUATION OF FLOATING FENOVERINE TABLETS
Authors :
Gulam Mehmood Afzal, Shahid Mohammed, Abdul Manan, Ramya Sri. S
Abstract :
Gastro-retentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract and improve the bioavailability of medications those are characterized by a narrow absorption window. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Fenoverine were prepared by direct compression method using altered concentrations of Carbopol, HPMC K 100 and Ethyl Cellulose as polymers. The prepared tablets of Fenoverine were evaluated tablet hardness, uniformity of weight, friability, uniformity of content, in vitro buoyancy test and in vitro dissolution study. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chemical interaction between pure drug and excipients. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution studies, dissolution parameters and drug released mechanisms. F5 formulation showed maximum floating time of 12 hours and gave slow and maximum drug release of Fenoverine spread over 12 hours. Finally the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.
Key words: Fenoverine, Carbopol, HPMC K 100, Ethyl Cellulose and Floating Tablets.
Cite This Article:
Please cite this article in press Gulam Mehmood Afzal et al, Formulation And Evaluation Of Floating Fenoverine Tablets.,Indo Am. J. P. Sci, 2024; 11 (06).
Number of Downloads : 10
References:
1. Leon lachman, Herbert a. Liberman, the theory and practice of industrial pharmacy: p.293-302.
2. Robinson jr, lee v.h.l, controlled drug delivery: fundamentals and applications, 2nd edn. Marcel Dekker, new york: (1978) p.24-36.
3. Brahmankar d.m, jaiswal s.b, biopharmaceutics and pharmacokinetics a treatise, 1st ed. Vallabh prakashan; New Delhi: (1995) p.64-70.
4. Chein y.w, novel drug delivery systems, 2nd ed.: marcel Dekker; New York: (1992) p.4-56.
5. Ansel, pharmaceutical dosage form and drug delivery system, lipincott, 7th edition: p. 553.
6. Gennaro r.a. Remington,the science and practice of pharmacy., 20th ed. New York: lippincott williams: (2000) p.1045.
7. Banker g.s, Rhodes c.t, modern pharmaceutics. 3rd ed. Marcel Dekker, New York: (1996) p.678-721.
8. Vyas s.p, khar r.k, controlled drug delivery: concepts and advances, 1st ed. Vallabh prakashan, new delhi: (2002) p.345-376.
9. Shweta arora, floating drug delivery: a review, aaps Pharmscitech. (2005): 47(11); p.268-272.
10. Libo yang, a new intragastric delivery system for the treatment of h.pylori associated with gastric ulcers, elsevier j. Of controlled release., apr(1999): 34 (5); p. 215-222.
11. Ross and wilson, anatomy physiology and health education. 9th ed. Churchil livingston, p. 295-311.
12. Wilson k.r.w, waugh a. Anatomy and physiology in health and illness, 9th ed. Churchill livingstone: london: (1996). P. 342-345.
13. Garima chawla- a means to address regional variability in intestinal drug absorption: pharmtech., (2003) p.234-238.
14. Chawla g, gupta p, koradia v, bansal a, gastroretention: a means to address regional variability in intestinal drug absorption, pharm. Tech., (2003); p.50-68.
15. Desai s, bolton s. A floating controlled release system: in-vitro and in-vivo evaluation, j. Pharm. Res., (1993): 10; p.1321-1325.
16. Garg s, sharma s. Gastroretentive drug delivery systems, pharmatech, (2003): p.160-164.
17. Dr.jose, khalid shah, gastroretentive drug delivery system, business brief, pharmtech., (2003) p. 165-173.
18. Deshpande a.a, shah n.h, rhodes c.t, development of a novel controlled release system for gastric retention, j. Pharm. Res., (1997): 14(6); p. 815-819.
19. Garima chawla- a means to address regional variability in intestinal drug absorption: pharmtech., (2003) p.234-238.
20. David s.s. The effect of density on the gastric emptying on single and multiple unit dosage forms. J. Pharm res., (1986): 3; p.208-213.
21. Ramya Sri Sura and Pavani S. Formulation And Evaluation Of Bioadhesive Buccal Tablets Of Mosapride Citrate. World journal of pharmaceutical research. 2014; 3(10): 1545-76.
22. Ramya Sri Sura, CVS Subrahmanyam, Shyam Sunder Rachamalla. Design And Evaluation Of Liquisolid Compacts Of nebivolol Hydrochloride (2022). Design and Evaluation of liquisolid compacts of nebivolol hydrochloride. International journal of applied pharmaceutics., 14(2), 293-307.
23. Ramya Sri Sura, Subrahmanyam CVS , Shyam Sunder Rachamalla. Development and evaluation of self micro emulsifying drug delivery system (SMEDDS) for nebivolol hydrochloride (2021). Int. J. Life Sci. Pharma Res. 11(6), P83-97. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.P83-97.