Volume : 10, Issue : 08, August – 2023
Title:
11.FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE EXPANDABLE FILM OF ENALAPRIL MALEATE WITH DIFFERENT EUDRAGIT POLYMERS
Authors :
Shreeya M S *, Mrs. Jyothi M, Dr.Chandrakala.V , Rashmi G
Abstract :
The present study illustrates the formulation and in vitro evaluation of gastroretentive expandable film of Enalapril maleate. These films were prepared using Enalapril maleate, Eudragit RSPO and RL 100, HPMC, dichloromethane, ethanol and PEG 400 by solvent evaporation technique. Five different formulations were prepared with individual and combination of two Eudragit polymers. The evaluation parameters of the polymeric films comprising two different property Eudragit polymers were studied. These formulations were subjected to unfolding behavior which showed 10 to 15 mins.In-vitro drug release was studied to understand the drug release in these five formulations. Surface morphology and drug compatibility of this films were studied through Scanning electron microscopy and FTIR technique.
Keywords : Enalapril maleate; Eudragit RSPO; Eudragit RL 100; Solvent evaporation technique; Scanning electron microscopy; Fourier transform infrared spectroscopy.
Cite This Article:
Please cite this article in press Shreeya M S et al, Formulation And In Vitro Evaluation Of Gastroretentive Expandable Film Of Enalapril Maleate With Different Eudragit Polymers, Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
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