Volume : 10, Issue : 08, August – 2023
Title:
24.DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL BIS-L-PROLINE INTERCALATORS AS POSSIBLE ANTICANCER AGENTS
Authors :
Saarangi Ramesh*, NJP Subhasini , T. Parthasarathy
Abstract :
In the present study, L-proline derivatives and linker chains are designed, synthesized and were characterized using spectral analysis. In the present study, 14 L-proline derivatives were synthesised among which five derivatives were consisting of symmetrical linker chains and nine derivatives are of asymmetrical linker chains. The synthesised compounds are then interacted through H-bond interactions with Topoisomerase-I (Human DNA) enzyme active sites. The docking analysis of L-proline derivative reveals that, among 14 compounds synthesised, compound IVL6 and IIIL4 were found to be more potent towards Topoisomerase-I enzyme with London dG scoring values of -12.8472 and -11.5501 respectively. All the synthesized compounds were then characterized using spectral analysis. Hence the present study forms the basis for the synthesis and characterization of L-proline derivatives as possible bis-intercalators to potentially act as anticancer agents.
Key words: Topoisomerase I enzyme, L-proline derivatives, docking analysis, H-bond interactions and anticancer agents.
Cite This Article:
Please cite this article in press Saarangi Ramesh et al, Design, Synthesis And Molecular Docking Studies Of Novel Bis-L-Proline Intercalators As Possible Anticancer Agents, Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
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