Volume : 10, Issue : 08, August – 2023

Title:

38.FORMULATION AND EVALUATION OF CONTROLLED RELEASE TABLETS OF PERINDOPRIL ERBUMINE
‬

Authors :

V. Sreenu, Devara Raj kumar

Abstract :

Perindopril Erbumine (PE) is an ACE inhibitor. It is effective in the treatment of Hypertension and Blood pressure, has a half-life 0.8-1 h and oral bioavailability is < 60 %. The objectives of the present research work are to formulate and evaluate controlled matrix tablets containing Perindopril Erbumine (PE) as a drug using different ratios of polymers to avoid hepatic first pass metabolism and to increase bioavailability of the drug. Different matrix carriers’ hydroxy methyl cellulose (HPMC) K100M, Xanthan gum, Micro Crystalline Cellulose, Poly Vinyl Pyrrolidone like were used to develop matrix tablets. Various pre-compression characteristics of the powder bed like bulk density, tapped density, compressibility index, and repose angle were evaluated and studied. Matrix tablets were compressed and were all assessed for weight variation, hardness, thickness, friability, swelling index, in vitro release of the drug. The conditions were simulated and sink conditions were maintained. Further stability studies of the Perindopril Erbumine formulation F9 conducted according to ICH guidelines at 40 ±20 °C and 75 ±5% RH for a period of 90 days.
Keywords: Perindopril Erbumine, Hypertension, Matrix carriers, Stability studies.

Cite This Article:

Please cite this article in press V. Sreenu et al, Formulation And Evaluation Of Controlled Release Tablets Of Perindopril Erbumine, Indo Am. J. P. Sci, 2023; 10 (08).

Number of Downloads : 10

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