Volume : 10, Issue : 08, August – 2023
Title:
39.ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE
Authors :
Amale lalaso Shankar , Devara Raj kumar
Abstract :
Despite significant advancements in the science of drug delivery, solubilization of poorly aqueous soluble drugs still remains a challenging task for formulation. The purpose of the study was to improve the physicochemical properties of poorly aqueous soluble drug Carvedilol like solubility, dissolution properties and stability of poorly soluble drug by forming dispersion with skimmed milk powder as carrier. Carvedilol was formulated by solid dispersions using rota-evaporation method and lyophilization method in different ratios 1:1 to 1:12 of drug and carrier (skimmed milk powder). The formulations were evaluated for various in vitro parameters (Drug content, Drug release, phase solubility studies, dissolution efficiency, FTIR) as well as changes in the physical state during storage under different humidity conditions. In vitro dissolution showed that increment of dissolution rate in case of SD than pure drug. Carevdilol phosphate with skimmed milk (1:6) showed the better results, maximum amount of drug released within 7 hours. It observed that no change in structure but change in physical state of the drug from crystalline to amorphous. The IR spectra of the drug, skimmed milk and the solid dispersion were performed to detect the possible molecular interaction between drug and carrier. The all above characteristics peaks of drug appear in the spectra of all ternary system at same wave number no modification or no interaction of the drug and carrier.
Keywords: Carvedilol, Solid dispersions, Skimmed milk, Carrier, FTIR, in-vitro release.
Cite This Article:
Please cite this article in press Amale lalaso Shankar et al, Enhancement Of Solubility And Dissolution Of Carvedilol By Solid Dispersion Technique , Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
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