Volume : 10, Issue : 08, August – 2023
Title:
41.MOUTH DISSOLVING TABLETS OF TOLFENAMIC ACID: DESIGN FORMULATION AND INVITRO EVALUATION
Authors :
Md.Mohiuddin*, Dr.Pawan Kumar, Dr. Syed Areefullah Hussainy
Abstract :
The study aimed to create easily dissolving tablets for an anti-nausea drug using synthetic substances that speed up disintegration. The Cross carmellose sodium ( 2-8%) from a synthetic source using direct compression. Testing involved extracting the drug from the prepared tablets with solutions of 0.1 N HCL and pH 7.2 phosphate buffer, measuring absorbance at 262.7nm. Post-compression tests were also conducted.
These tests included examining how the drug was released in different solutions, stability over six months at 40ºC/75% RH, and any interactions between the drug and other substances using IR spectroscopy. The formulations with 8% cros carmellose sodium , stood out as the most promising (FM8) formulation.
Short-term stability assessments of these successful formulations showed no significant changes in drug content or in how quickly they dispersed in solution (p<0.05). IR spectroscopy revealed no interactions between the drug and other components. Overall, this study indicates that natural disintegrants, particularly CCS outperformed other ones, resulting in improved dissolution of the drug.
Keywords: Tolfenamic acid, Sodium starch glycolate, Cross carmellose sodium,Direct compression method,FTIR.
Cite This Article:
Please cite this article in press Md.Mohiuddin et al, Mouth Dissolving Tablets Of Tolfenamic Acid: Design Formulation And Invitro Evaluation, Indo Am. J. P. Sci, 2023; 10 (08).
Number of Downloads : 10
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