Volume : 10, Issue : 12, December – 2023

Title:

SYNTHESIS AND INSILICO EVALUATION OF 4,6-DIPHENYL PYRIMIDINE-2(1H)-THIONE DERIVATIVES

Authors :

Sudha Rani. K*, Sowmya. A, K. Durga Lalitha Rani, A. Teja, B. Bhavana, V. Mythili, D. Kiranmayee

Abstract :

A Series of Bioactive compounds, 4,6-diphenyl pyrimidine-2(1H)-thione(1a), 4-(4-cholophenyl)-6-phenylpyrimidine-(1H)-thione(1b),4-(4-aminophenyl)-6-phenyl pyrimidine-2(1H)-thione(1c), 4-(4-nitrophenyl)-6-phenyl pyrimidine -2(1H)-thione(1d), 4-(4-methoxyphenyl)-6-phenylpyrimidine-2(1H)-thione(1e), were Synthesized according to the Literature methods. The Synthesized compounds were characterized by NMR, IR & Mass Spectroscopy.
Keywords: 4,6-diphenyl pyridine-3(2H)-one, chalcones, aldehydes, thiourea.

Cite This Article:

Please cite this article in press Sudha Rani. K et al Synthesis And Insilico Evaluation Of 4,6-Diphenyl Pyrimidine-2(1h)-Thione Derivatives, Indo Am. J. P. Sci, 2023; 10 (12).

Number of Downloads : 10

References:

1. Sasada, T: Kobayashi, F,Sakai,N,;Konakahara,T,org. Lett,2009,11,2161-2164.
2. Dinakaran, V.S; Bomma, B,;Srinivasn, K K, Der Pharma Chem 2012,4,255-265.
3. Pratyusha, C,; Poornima, G.; Rani, K.S.; Krishnavaeni, A.; Brahmaiah, B.; Nama, S.Int,J. Pharm. Sci. Rev. Res. 2013, 3, 86-90.
4. Jain, K.S.; Chitre. T.S.; Miniyar, P.B.; Kathiravan, M.K.; Bendre, V. S.; Veer, V. S.; Shahane, S. R.; Shishoo, C.J.Curr. Sci. 2006, 90, 793-803.
5. Sathisha, K.R.; Gopal, S.; Rangapp, K.S. World J. Pharm. Res. 2015, 5, 1467-1491.
6. Ghoneim K M and Youssef R, J. Indian Chem Soc, 1986, 53, 914.
7. Tetko IV. Computering chemistry on the web. Drug Discov Today 2005; 10:1497-1500.
8. Organic Chemistry Portal, http://www.organicchemistry. Org/prog/peo/22 May, 2012.