Volume : 10, Issue : 12, December – 2023
Title:
FORMULATION AND EVALUATION OF TOLFENAMIC ACID MOUTH DISSOLVING TABLETS USING DIFFERENT SUPERDISINTEGRANTS
Authors :
Md. Mohiuddin*, Pawan Kumar, Syed Areefullah Hussainy
Abstract :
The current study aimed to create and assess mouth-dissolving tablets containing Tolfenamic acid using different superdisintegrants such as Sodium starch glycolate (SSG), Crospovidone (CP), and Microcrystalline Cellulose (MCC). Variations in the concentrations of these superdisintegrants were employed to enhance the release rates. Tablets were prepared using direct compression technique, incorporating varied concentrations of different superdisintegrants. Pre-compression and post-compression assessments including Bulk density, Tapped density, Angle of repose, Cars index, Hauser’s ratio, etc., were conducted. Post-compression evaluations encompassed thickness, weight variation, hardness, friability, uniformity of drug content, and dissolution studies. The in-vitro drug release study in 0.1N NaOH for 5 minutes and in phosphate buffer pH 6.8 for 30 minutes indicated that formulations F4 and F8 exhibited the maximum drug release within 1 minute, attributed to the presence of Crospovidone, demonstrating cumulative drug releases of 99.86% and 99.97%, respectively. Consequently, these formulations were deemed optimal and subjected to stability studies over three months, during which their pre-compression and post-compression properties were re-evaluated, revealing no significant changes.
Keywords: Mouth dissolving tablets, Tolfenamic acid, Sodium starch glycolate, Direct compression method.
Cite This Article:
Please cite this article in press Md.Mohiuddin et al, Formulation And Evaluation Of Tolfenamic Acid Mouth Dissolving Tablets Using Different Superdisintegrants, Indo Am. J. P. Sci, 2023; 10 (12).
Number of Downloads : 10
References:
1. Kuchekar BS, Bhise SB, and Arungam V. Development of Rapidly Dissolving Tablets. Indian Journal of Pharmaceutical Education 2005;35:150.
2. Slowson M and Slowson S. Managing Medications for Patients Unable to Swallow. Pharma Times 1985;51:90‐96.
3. Indurwade NH, Rajyaguru TH, and Nakhat PD. Innovative Approach: Rapidly Dissolving Tablets. Indian Drugs 2002;39(8):405-41.
4. Seager HJ. Zydis Fast-Dissolving Dosage Forms in Drug Delivery Products. Pharmaceutical Pharmacology 1998;50:375-382.
5. Gohel M, Patel M, Amin A, Agrawal R, Dave R, and Bariya N. Development and Optimization of Mouth Dissolving Tablets of Nimesulide Using Vacuum Drying Technique. AAPS PharmSciTech 2004;5:36.
6. Arya A, Chandra A. Swift Drug Delivery Systems: A Review. Scholars Research Library 2010; 02(02):350-361.
7. Reddy LH, Ghosh B, and Rajneesh. Rapid Dissolving Drug Delivery Systems: A Literature Review. Indian Journal of Pharmaceutical Sciences 2002;64(4):331‐336.
8. Habib W, Khankari R, and Hontz J. Swift-Dissolving Drug Delivery Systems: Critical Review in Therapeutics. Drug Carrier Systems 2002;17(1):61-72.
9. Bradoo R, Shahani S, Poojary S, Deewan B, and Sudarshan S. Swift Dissolving Drug Delivery Systems. JAMA India 2001;4(10):27‐31.
10. Biradar SS, Bhagavati ST, and Kuppasad IJ. Swift Dissolving Drug Delivery Systems: A Brief Overview. The International Journal of Pharmacology 2006;4(2).
11. Bhaskaran S, Narmada GV. Rapidly Dissolving Tablets: An Innovative Dosage Form. Indian Pharmacist 2002;1:9-12.
12. Devrajan PV and Gore SP. Melt-in-Mouth Tablets: Innovative Oral Drug Delivery System. Express Pharma Pulse 2000;7(1):16.
13. Ghosh T, Ghosh A, Prasad D. Review on Next-Generation Orodispersible Tablets and Their Future Prospects. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 03(01): 1-7.
14. Parakh SR and Gothoskar AV. Examination of Technologies for Mouth Dissolving Tablets. Pharmaceutical Technology 2003;27(11):92-98.
15. Mizumoto T, Masuda Y, and Fukui M. Intrabuccally Dissolving Compressed Moldings and Their Production Process. US Patent 1996; No. 5576014.
16. Nail SL and Gatlin LA. Freeze Drying Principles and Practice, Parenteral Medications in Pharmaceutical Dosage Forms. 2nd ed. Vol. 2. Marcel Dekker, New York; 1993: 163.
17. Kuchekar BS, Badhan CA, and Mahajan HS. Mouth Dissolving Tablets: A Novel Drug Delivery System. Pharma Times 2003;35:7-10.
18. Yarwood RJ, Kearny P, and Thomson AR. Procedure for Creating Solid Pharmaceutical Dosage Forms. US Patent 1998; No. 5738875.