Volume : 10, Issue : 12, December – 2023

Title:

MATERNAL AND FETAL OUTCOMES AMONG WOMEN WHO MISSED GLUCOSE TOLERANCE TEST DURING THEIR PREGNANCY AS A RESULT OF THE COVID-19 CRISIS

Authors :

Dr.Nehad Hamad Hamed Almajnoni, Dr.Issam Bin Ali ,

Abstract :

Background: The lockdown imposed during the early phase of the COVID-19 pandemic has impeded access to antenatal care including gestational diabetes mellitus (GDM) screening, notably between 23 March-28 May 2020, period of strict lockdown.
Objectives: To estimate the impact of missed GDM screening during COVID-19 lockdown on short-term maternal and fetal outcomes.
Methods: A retrospective cohort was conducted to identify all pregnant women whose regular screening period, i.e., gestational age 24-28 weeks, coincided with COVID-19 lockdown period (exposed group, N=142), and to compare their maternal and fetal outcomes with an equivalent-size sample of 142 consecutive pregnant woman who benefited from GDM screening during the two months preceding the lockdown (unexposed group).
Results: In unexposed group, GDM screening showed GDM prevalence of 43.0% (95%CI = 34.7–51.5%), and half (50.8%) were adequately treated. No significant differences in maternal or fetal outcomes were observed between exposed and unexposed groups. Postpartum screening, carried out among 60 (42.6%) of exposed women, showed 14 (23.3%) positive cases. Postpartum GDM cases together with prenatally diagnosed but inadequately treated ones were compared with adequately treated GDM cases, and showed significantly higher incidence of neonatal hypoglycemia (15.8% versus 0.0%, p=0.049) and neonatal intensive care admissions (36.8% versus 3.2%, p=0.003), with relatively higher, but not statistically significant, birthweight (3286.95 versus 3034.52, p=0.075) respectively.
Conclusion: The strict lockdown measures imposed in Saudi Arabia during the early phase of the COVID-19 pandemic was associated with inadequate screening and treatment of GBM, which resulted in increased maternal and fetal risks.
Keywords: Gestational diabetes; screening; COVID-19; lockdown; maternal outcome; fetal outcome

Cite This Article:

Please cite this article in press Nehad Hamad Hamed Almajnoni et al., Maternal And Fetal Outcomes Among Women Who Missed Glucose Tolerance Test During Their Pregnancy As A Result Of The Covid-19 Crisis.,, Indo Am. J. P. Sci, 2023; 10 (12).

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References:

1. Benhalima K, van Crombrugge P, Moyson C, Verhaeghe J, Vandeginste S, Verlaenen H, et al. Characteristics and pregnancy outcomes across gestational diabetes mellitus subtypes based on insulin resistance. Diabetologia [Internet]. 2019;62(11):2118–28. Available from: https://doi.org/10.1007/s00125-019-4961-7
2. Heida KY, Franx A, van Rijn BB, Eijkemans MJC, Boer JMA, Verschuren MWM, et al. Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus. Hypertension [Internet]. 2015 Dec;66(6):1116–22. Available from: https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.06005
3. International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Diabetes Care [Internet]. 2010 Mar 1;33(3):676–82. Available from: http://care.diabetesjournals.org/cgi/doi/10.2337/dc09-1848
4. Bener A. Prevalence of gestational diabetes and associated maternal and neonatal complications in a fast-developing community: global comparisons. International Journal of Women’s Health [Internet]. 2011 Nov;367. Available from: http://www.dovepress.com/prevalence-of-gestational-diabetes-and-associated-maternal-and-neonata-peer-reviewed-article-IJWH
5. Groof Z, Garashi G, Husain H, Owayed S, AlBader S, Mouhsen H, et al. Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study. Journal of Diabetes Research [Internet]. 2019 Mar 3;2019:1–7. Available from: https://www.hindawi.com/journals/jdr/2019/9136250/
6. Alfadhli EM, Osman EN, Basri TH, Mansuri NS, Youssef MH, Assaaedi SA, et al. Gestational diabetes among Saudi women: prevalence, risk factors and pregnancy outcomes. Annals of Saudi Medicine [Internet]. 2015 May;35(3):222–30. Available from: http://www.annsaudimed.net/doi/10.5144/0256-4947.2015.222
7. Jiwani A, Marseille E, Lohse N, Damm P, Hod M, Kahn JG. Gestational diabetes mellitus: results from a survey of country prevalence and practices. The Journal of Maternal-Fetal & Neonatal Medicine [Internet]. 2012 Jun 15;25(6):600–10. Available from: http://www.tandfonline.com/doi/full/10.3109/14767058.2011.587921
8. Buchanan TA, Xiang AH, Page KA. Gestational diabetes mellitus: risks and management during and after pregnancy. Nature Reviews Endocrinology [Internet]. 2012 Nov 3;8(11):639–49. Available from: http://www.nature.com/articles/nrendo.2012.96
9. Akseer N, Kandru G, Keats EC, Bhutta ZA. COVID-19 pandemic and mitigation strategies: implications for maternal and child health and nutrition. The American Journal of Clinical Nutrition [Internet]. 2020 Aug 1;112(2):251–6. Available from: https://academic.oup.com/ajcn/article/112/2/251/5860091
10. Mission JF, Ohno MS, Cheng YW, Caughey AB. Gestational diabetes screening with the new IADPSG guidelines: a cost-effectiveness analysis. American Journal of Obstetrics and Gynecology [Internet]. 2012 Oct;207(4):326.e1-326.e9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S000293781200662X
11. Marseille E, Lohse N, Jiwani A, Hod M, Seshiah V, Yajnik CS, et al. The cost-effectiveness of gestational diabetes screening including prevention of type 2 diabetes: application of a new model in India and Israel. The Journal of Maternal-Fetal & Neonatal Medicine [Internet]. 2013 May 14;26(8):802–10. Available from: http://www.tandfonline.com/doi/full/10.3109/14767058.2013.765845
12. Fitria N, van Asselt ADI, Postma MJ. Cost-effectiveness of controlling gestational diabetes mellitus: a systematic review. The European Journal of Health Economics [Internet]. 2019 Apr 18;20(3):407–17. Available from: http://link.springer.com/10.1007/s10198-018-1006-y
13. Karatas S, Yesim T, Beysel S. Impact of lockdown COVID-19 on metabolic control in type 2 diabetes mellitus and healthy people. Primary Care Diabetes [Internet]. 2021 Jan; Available from: https://linkinghub.elsevier.com/retrieve/pii/S1751991821000036
14. Murphy HR. Managing Diabetes in Pregnancy Before, During, and After COVID-19. Diabetes Technology & Therapeutics [Internet]. 2020 Jun 1;22(6):454–61. Available from: https://www.liebertpub.com/doi/10.1089/dia.2020.0223
15. Khan R, Ali K, Khan Z. Maternal and fetal outcome of gestational diabetes mellitus. Gomal Journal of Medical Sciences. 2013;11(1).
16. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nature Reviews Disease Primers [Internet]. 2019 Dec 11;5(1):47. Available from: http://www.nature.com/articles/s41572-019-0098-8
17. Soffer M, Bigelow CA, Clunie G. Gestational Diabetes. In: Obstetrics and Gynecology [Internet]. Wiley; 2020. p. 21–7. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119450047.ch03
18. Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications. Trends in Endocrinology & Metabolism [Internet]. 2018 Nov;29(11):743–54. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1043276018301656
19. KC K, Shakya S, Zhang H. Gestational Diabetes Mellitus and Macrosomia: A Literature Review. Annals of Nutrition and Metabolism [Internet]. 2015;66(Suppl. 2):14–20. Available from: https://www.karger.com/Article/FullText/371628
20. Farahvar S, Walfisch A, Sheiner E. Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review. Expert Review of Endocrinology & Metabolism [Internet]. 2019 Jan 2;14(1):63–74. Available from: https://www.tandfonline.com/doi/full/10.1080/17446651.2018.1476135
21. Kelley K, Carroll D, Meyer A. A review of current treatment strategies for gestational diabetes mellitus. Drugs in Context [Internet]. 2015 Jul 15;4:1–15. Available from: http://www.drugsincontext.com/a-review-of-current-treatment-strategies-for-gestational-diabetes-mellitus
22. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nature Reviews Disease Primers [Internet]. 2019 Dec 11;5(1):47. Available from: http://www.nature.com/articles/s41572-019-0098-8
23. Guo L, Ma J, Tang J, Hu D, Zhang W, Zhao X. Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis. Journal of Diabetes Research [Internet]. 2019 Nov 4;2019:1–29. Available from: https://www.hindawi.com/journals/jdr/2019/9804708/