Volume : 10, Issue : 02, February – 2023

Title:

41.IN VITRO ANTICATARACT ACTIVITY OF TAMARINDUS INDICA LINN. AGAINEST GLUCOSE-INDUCED CATARACTOGENISIS
‬

Authors :

S. K Godasu, Nimma vijayarekha , G. Anusha , D. Varun , Praveen Gujjula

Abstract :

The main objective of the present study is to screen the hydromethanolic extract of Tamarindus indica Linn. for its in vitro anticataract activity against glucose-induced cataractogenesis using goat lenses. Phytochemical screening of the powdered leaves of Tamarindus indica showed the presence of phenolics, tannins, saponins, flavonoids and alkaloids. Incubation with the hydromethanolic leaf extract of Tamarindus indica at doses of (100 & 200 µg/ml) and Vitamin E (100 µg/ml) simultaneously with glucose for 72 h caused a significant (P<0.01) increase in the total protein and a decrease in the level of malondialdehyde and lipid hydroperoxides. Incubation with the hydromethanolic leaf extract of Tamarindus indica at doses of (100 & 200 µg/ml) and Vitamin E simultaneously with glucose significantly (P<0.01) restored the levels of both enzymatic and non-enzymatic antioxidant enzymes which is almost similar to the control group. the study suggested that the leaf extract of Tamarin dus indica possess anticataract and antioxidant activities, which might be helpful in preventing or slowing the progress of cataract. Further investigations on the isolation and identification of active components in the leaves may lead to chemical entities with potential for clinical use in the prevention and treatment of cataract.
Key words: In Vitro, Anticataract Activity, Tamarindus Indica Linn, Glucose-Induced Cataractogenisis

Cite This Article:

Number of Downloads : 10

References:

1. Murthy G, Gupta SK, John N, Vashist P (2008) Current status of cataract blindness and Vision 2020: the right to sight initiative in India. Indian J Ophthalmol 56(6): 489-494.
2. Thylefors B (1999) Avoidable blindness. Bull World Health Organ 77(6): 453.
3. Kyselova Z, Stefek M, Bauer V (2004) Pharmacological prevention of diabetic cataract. J Diabetes Complications 18(2): 129-140.
4. Gupta SK, Srivastava S, Trivedi D, Joshi S, Nabanita H (2005) Ocimum sanctum modulates selenite-induced cataractogenic changes and prevents rat lens opacification. Curr Eye Res 30(7): 583-591.
5. Suryanarayana P, Anil Kumar P, Saraswat M, Mark P, Reddy GB (2004) Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract. Mol Vis 10: 148-154.
6. Ughade SN, Zodpey SP, Khanolkar VA (1998) Risk factors for cataract: a case control study. Indian J Opthalmol 46(4): 221-227.
7. Marcelo NA, Soderbeg PG (2004) Vitamin E can protect against ultraviolet radiation-induced cataract in albino rats. Opthalmic Res 36(5): 264-269.
8. Langade DG, Rao G, Girme RC, Patki PS, Bulakh PM (2006) Prevention by ACE inhibitors of cataract induced by glucose. Indian J Pharmacol 38(2): 107-110.
9. Harding JJ, Egerton M, Heyningen R, Harding RS (1993) Diabetes, glaucoma, sex, and cataract: analysis of combined data from two case control studies. British J Ophthalmol 77(1): 2-6.
10. Andreas P, Ursula SE (2010) Diabetic Cataract-Pathogenesis, Epidemiology and Treatment. J Ophthalmol 10: 1-9.
11. Reddy VN, Garadi R, Chakrapani B, Giblin FJ (1988) Effect of glutathione depletion on cation transport and metabolism in the rabbit lens. Opthalmic Res 20(3): 191-199.
12. Gupta SK, Halder N, Srivastava S, Trivedi D, Joshi S (2002) Green Tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis. Opthalmic Res 34(4): 258-263.
13. Yadav S, Vats Y, Dhunnoo, Grover JK (2002) Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. J Ethanopharmacol 82(2-3): 111-116.
14. Mihir Y Parmar (2016) Protective effect of lutein supplementation on oxidative stress and inflammatory progression in cerebral cortex of streptozotocin-induced diabetes in rats. Neurochem J 10(1): 69-76.