Volume : 10, Issue : 02, February – 2023

Title:

48.FORMULATION AND EVALUATION OF HMG-CoA REDUCTASE INHIBITOR NANOPARTICLES
‬

Authors :

Y. Ramulu

Abstract :

The present work was proposed to prepared nanoparticles loaded with Rosuvastatin to achieved better bioavailability with low dose of the drug at the site, decreased the risk of adverse side effects. Rosuvastatin nanoparticles were prepared by in-situ two step desolvation method. The loading efficiency(F1) and Entrapment efficiency(F1) was 66.21 and 91.73 respectively. The shape of nanoparticle was found to be spherical by SEM analysis. Formulation with high polymer content was observed to be fairly spherical. Compatability of drug and polymer mixture was done by performing FTIR and DSC study. It was concluded that there was no interaction between drug and polymer. The in-vitro released of Rosuvastatin was evaluated in phosphate buffer saline (pH6.8) up to 16hrs. The formulation F1 was released the drug 93.38% up to16 hours. and chosen the best among the formulations were prepared. Zeta potential was determined for the formulation F1 and it was found to be +ve value of 1.57mv. The in-vitro drug released data was applied to various kinetic models like zero order kinetics, Higuchi plot, first order kinetics, and Peppas plot by predict the drug release kinetics mechanism. The formulation F1 was best fitted the zero order kinetics. In short term stability studies the formulation F1 was showed that there was no remarkable changes in the % drug loading efficiency. Based on the % drug loading efficiency, zeta potential, in-vitro drug release profile, in-vitro drug release kinetics and stability studies the formulation F1 was found to be best one among the formulations (F1 to F8) were prepared. These nanoparticles can be promising agents for rational drug delivery in lipidemic condition.
Keywords: Formulation, Characterization, Rosuvastatin, Nanoparticles

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Number of Downloads : 10

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